Stem cell therapy for ischemic heart disease

Mohammad Nurulqadr Jameel, Jianyi J Zhang

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Stem cell transplantation has emerged as a novel treatment option for ischemic heart disease. Different cell types have been utilized and the recent development of induced pluripotent stem cells has generated tremendous excitement in the regenerative field. Bone marrow-derived multipotent progenitor cell transplantation in preclinical large animal models of postinfarction left ventricular remodeling has demonstrated long-term functional and bioenergetic improvement. These beneficial effects are observed despite no significant engraftment of bone marrow cells in the myocardium and even lower differentiation of these cells into cardiomyocytes. It is thought to be related to the paracrine effect of these stem cells, which secrete factors that lead to long-term gene expression changes in the host myocardium, thereby promoting neovascularization, inhibiting apoptosis, and stimulating resident cardiac progenitor cells. Future studies are warranted to examine the changes in the recipient myocardium after stem cell transplantation and to investigate the signaling pathways involved in these effects.

Original languageEnglish (US)
Pages (from-to)1879-1897
Number of pages19
JournalAntioxidants and Redox Signaling
Volume13
Issue number12
DOIs
StatePublished - Dec 15 2010

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