Steerable nanobots for diagnosis and therapy

Anirudh Sharma, Yuechen Zhu, Madhukar Reddy, Allison Hubel, Ryan Cobian, Liwen Tan, Bethanie Stadler

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

This paper reviews the synthesis of magnetic multilayerd nanowires that have a wide range of applications. Specifically of interest in this review are the applications of magnetic manipulation and separation of cells, which are important for potential cancer therapies. Compared to other magnetic nanoparticles in use today, the nanowires have the advantage of being ferromagnetic and also having high aspect ratios that enable barcoding. These nanobots are synthesized inside nanoporous oxide templates in large batches (1012 per square inch), and they can be composed of any magnetic metal, alloy, or multilayer that can be electroplated. Specific details for the electrochemistry of Galfenol deposition are given. Galfenol is an exciting new magnetostrictive material with durable mechanical properties. Next, a protocol is described for full removal of the growth contact prior to release of the nanobots from their oxide template. This mitigates aggregation which inhibits cellular uptake. Feasibility of manipulation and separation was shown using canine bone cancer (os-teosarcoma) cells which internalized the nanobots, enabling magnetic cellular control. In addition, initial toxicity studies indicate that the nanobots are not cytotoxic. These studies merely scratch the surface of the potential use of nanobots for diagnosis and therapy in the near future.

Original languageEnglish (US)
Title of host publicationUniverse of Scales
Subtitle of host publicationFrom Nanotechnology to Cosmology - Symposium in Honor of Minoru M. Freund
EditorsFriedemann Freund, Stephanie Langhoff
PublisherSpringer Science and Business Media, LLC
Pages179-189
Number of pages11
ISBN (Print)9783319022062
DOIs
StatePublished - Jan 1 2014
EventUniverse of Scales: From Nanotechnology to Cosmology Symposium in Honor of Minoru M. Freund, 2014 - Moffett Field, United States
Duration: Jan 1 2014 → …

Publication series

NameSpringer Proceedings in Physics
Volume150
ISSN (Print)0930-8989
ISSN (Electronic)1867-4941

Conference

ConferenceUniverse of Scales: From Nanotechnology to Cosmology Symposium in Honor of Minoru M. Freund, 2014
CountryUnited States
CityMoffett Field
Period1/1/14 → …

Fingerprint Dive into the research topics of 'Steerable nanobots for diagnosis and therapy'. Together they form a unique fingerprint.

Cite this