This paper reviews the synthesis of magnetic multilayerd nanowires that have a wide range of applications. Specifically of interest in this review are the applications of magnetic manipulation and separation of cells, which are important for potential cancer therapies. Compared to other magnetic nanoparticles in use today, the nanowires have the advantage of being ferromagnetic and also having high aspect ratios that enable barcoding. These nanobots are synthesized inside nanoporous oxide templates in large batches (1012 per square inch), and they can be composed of any magnetic metal, alloy, or multilayer that can be electroplated. Specific details for the electrochemistry of Galfenol deposition are given. Galfenol is an exciting new magnetostrictive material with durable mechanical properties. Next, a protocol is described for full removal of the growth contact prior to release of the nanobots from their oxide template. This mitigates aggregation which inhibits cellular uptake. Feasibility of manipulation and separation was shown using canine bone cancer (os-teosarcoma) cells which internalized the nanobots, enabling magnetic cellular control. In addition, initial toxicity studies indicate that the nanobots are not cytotoxic. These studies merely scratch the surface of the potential use of nanobots for diagnosis and therapy in the near future.
|Original language||English (US)|
|Title of host publication||Universe of Scales|
|Subtitle of host publication||From Nanotechnology to Cosmology - Symposium in Honor of Minoru M. Freund|
|Editors||Friedemann Freund, Stephanie Langhoff|
|Publisher||Springer Science and Business Media, LLC|
|Number of pages||11|
|State||Published - 2014|
|Event||Universe of Scales: From Nanotechnology to Cosmology Symposium in Honor of Minoru M. Freund, 2014 - Moffett Field, United States|
Duration: Jan 1 2014 → …
|Name||Springer Proceedings in Physics|
|Conference||Universe of Scales: From Nanotechnology to Cosmology Symposium in Honor of Minoru M. Freund, 2014|
|Period||1/1/14 → …|
Bibliographical noteFunding Information:
This work was primarily supported by the Grant in Aid and the Institute for Engineering in Medicine Programs of the University of Minnesota and supported partially by the MRSEC Program of the National Science Foundation under Award Numbers DMR-0819885. Parts of this work were carried out in the University of Minnesota Nanofabrication Center, Characterization Facility, and the University Imaging Center, which receive partial support from NSF through the NNIN program. This review covers over a decade of work by the following past and current group members: Patrick McGary, Liwen Tan, Xiaobo Huang, Rajneeta Basantkumar, Sang-Yeob Sung, Xiaoyuan Zi, Ratnanjali Khandwal, Vladimir Makarov, Andrew Block, Eliot Estrine, Matthew Hein, Ryan Cobian, and Neal Speetzen.
© Springer International Publishing Switzerland 2014.