Abstract
Immune cells can metabolize glucose, amino acids, and fatty acids (FAs) to generate energy. The roles of different FA species and their impacts on humoral immunity remain poorly understood. Here, we report that proliferating B cells require monounsaturated FAs (MUFAs) to maintain mitochondrial metabolism and mTOR activity and to prevent excessive autophagy and endoplasmic reticulum (ER) stress. Furthermore, B cell-extrinsic stearoyl-CoA desaturase (SCD) activity generates MUFA to support early B cell development and germinal center (GC) formation in vivo during immunization and influenza infection. Thus, SCD-mediated MUFA production is critical for humoral immunity.
Original language | English (US) |
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Article number | 108601 |
Journal | Cell reports |
Volume | 34 |
Issue number | 1 |
DOIs | |
State | Published - Jan 5 2021 |
Bibliographical note
Publisher Copyright:© 2020 The Authors
Keywords
- B cell
- autophagy
- humoral immunity
- mTOR
- monounsaturated fatty acid
- stearoyl-CoA desaturase
PubMed: MeSH publication types
- Journal Article
- Research Support, Non-U.S. Gov't
- Research Support, N.I.H., Extramural