Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity

Xian Zhou, Xingxing Zhu, Chaofan Li, Yanfeng Li, Zhenqing Ye, Virginia Smith Shapiro, John A. Copland, Taro Hitosugi, David A. Bernlohr, Jie Sun, Hu Zeng

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Immune cells can metabolize glucose, amino acids, and fatty acids (FAs) to generate energy. The roles of different FA species and their impacts on humoral immunity remain poorly understood. Here, we report that proliferating B cells require monounsaturated FAs (MUFAs) to maintain mitochondrial metabolism and mTOR activity and to prevent excessive autophagy and endoplasmic reticulum (ER) stress. Furthermore, B cell-extrinsic stearoyl-CoA desaturase (SCD) activity generates MUFA to support early B cell development and germinal center (GC) formation in vivo during immunization and influenza infection. Thus, SCD-mediated MUFA production is critical for humoral immunity.

Original languageEnglish (US)
Article number108601
JournalCell reports
Issue number1
StatePublished - Jan 5 2021

Bibliographical note

Publisher Copyright:
© 2020 The Authors


  • B cell
  • autophagy
  • humoral immunity
  • mTOR
  • monounsaturated fatty acid
  • stearoyl-CoA desaturase

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural


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