Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity

Xian Zhou; Xingxing Zhu; Chaofan Li; Yanfeng Li; Zhenqing Ye; Virginia Smith Shapiro; John A. Copland; Taro Hitosugi; David A Bernlohr; Jie Sun; Hu Zeng

doi:10.1016/j.celrep.2020.108601

Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity

Xian Zhou, Xingxing Zhu, Chaofan Li, Yanfeng Li, Zhenqing Ye, Virginia Smith Shapiro, John A. Copland, Taro Hitosugi, David A Bernlohr, Jie Sun, Hu Zeng

Biochemistry, Molecular Biology, and Biophysics (TMED)

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Immune cells can metabolize glucose, amino acids, and fatty acids (FAs) to generate energy. The roles of different FA species and their impacts on humoral immunity remain poorly understood. Here, we report that proliferating B cells require monounsaturated FAs (MUFAs) to maintain mitochondrial metabolism and mTOR activity and to prevent excessive autophagy and endoplasmic reticulum (ER) stress. Furthermore, B cell-extrinsic stearoyl-CoA desaturase (SCD) activity generates MUFA to support early B cell development and germinal center (GC) formation in vivo during immunization and influenza infection. Thus, SCD-mediated MUFA production is critical for humoral immunity.

Original language	English (US)
Article number	108601
Journal	Cell reports
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/j.celrep.2020.108601
State	Published - Jan 5 2021

Bibliographical note

Publisher Copyright:
© 2020 The Authors

Keywords

B cell
autophagy
humoral immunity
mTOR
monounsaturated fatty acid
stearoyl-CoA desaturase

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

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10.1016/j.celrep.2020.108601

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title = "Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity",

abstract = "Immune cells can metabolize glucose, amino acids, and fatty acids (FAs) to generate energy. The roles of different FA species and their impacts on humoral immunity remain poorly understood. Here, we report that proliferating B cells require monounsaturated FAs (MUFAs) to maintain mitochondrial metabolism and mTOR activity and to prevent excessive autophagy and endoplasmic reticulum (ER) stress. Furthermore, B cell-extrinsic stearoyl-CoA desaturase (SCD) activity generates MUFA to support early B cell development and germinal center (GC) formation in vivo during immunization and influenza infection. Thus, SCD-mediated MUFA production is critical for humoral immunity.",

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author = "Xian Zhou and Xingxing Zhu and Chaofan Li and Yanfeng Li and Zhenqing Ye and Shapiro, {Virginia Smith} and Copland, {John A.} and Taro Hitosugi and Bernlohr, {David A} and Jie Sun and Hu Zeng",

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AU - Zhou, Xian

AU - Zhu, Xingxing

AU - Li, Chaofan

AU - Li, Yanfeng

AU - Ye, Zhenqing

AU - Shapiro, Virginia Smith

AU - Copland, John A.

AU - Hitosugi, Taro

AU - Bernlohr, David A

AU - Sun, Jie

AU - Zeng, Hu

PY - 2021/1/5

Y1 - 2021/1/5

N2 - Immune cells can metabolize glucose, amino acids, and fatty acids (FAs) to generate energy. The roles of different FA species and their impacts on humoral immunity remain poorly understood. Here, we report that proliferating B cells require monounsaturated FAs (MUFAs) to maintain mitochondrial metabolism and mTOR activity and to prevent excessive autophagy and endoplasmic reticulum (ER) stress. Furthermore, B cell-extrinsic stearoyl-CoA desaturase (SCD) activity generates MUFA to support early B cell development and germinal center (GC) formation in vivo during immunization and influenza infection. Thus, SCD-mediated MUFA production is critical for humoral immunity.

AB - Immune cells can metabolize glucose, amino acids, and fatty acids (FAs) to generate energy. The roles of different FA species and their impacts on humoral immunity remain poorly understood. Here, we report that proliferating B cells require monounsaturated FAs (MUFAs) to maintain mitochondrial metabolism and mTOR activity and to prevent excessive autophagy and endoplasmic reticulum (ER) stress. Furthermore, B cell-extrinsic stearoyl-CoA desaturase (SCD) activity generates MUFA to support early B cell development and germinal center (GC) formation in vivo during immunization and influenza infection. Thus, SCD-mediated MUFA production is critical for humoral immunity.

KW - B cell

KW - autophagy

KW - humoral immunity

KW - mTOR

KW - monounsaturated fatty acid

KW - stearoyl-CoA desaturase

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Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity

Abstract

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Keywords

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