TY - JOUR
T1 - Steady-state pharmacokinetics of fleroxacin in patients with skin and skin structure infections
AU - Heim-Duthoy, Karen L
AU - Peltier, G.
AU - Awni, W.
PY - 1990
Y1 - 1990
N2 - Steady-state pharmacokinetics of oral fleroxacin were studied in six males who had skin or skin structure infections and who were receiving 400 mg of fleroxacin once a day. Blood samples (n = 10) and total urine output were collected during a 24-h dosing interval. Fleroxacin concentrations in serum and urine were determined by high-performance liquid chromatography. The maximum concentration in serum and the time to achieve that maximum were 6.2 ± 2.2 μg/ml and 0.94 ± 0.62 h, respectively. The absorption half-life, alpha half-life, beta half-life, apparent steady-state volume of distribution, apparent total body clearance, and renal clearance were 0.56 ± 0.37 h, 0.78 ± 0.51 h, 10.56 ± 1.40 h, 0.85 ± 0.31 liters/kg, 129.2 ± 19.6 ml/min, and 53.3 ± 16.7 ml/min, respectively. Fleroxacin disposition in this patient population was similar to that in noninfected volunteers with normal renal function.
AB - Steady-state pharmacokinetics of oral fleroxacin were studied in six males who had skin or skin structure infections and who were receiving 400 mg of fleroxacin once a day. Blood samples (n = 10) and total urine output were collected during a 24-h dosing interval. Fleroxacin concentrations in serum and urine were determined by high-performance liquid chromatography. The maximum concentration in serum and the time to achieve that maximum were 6.2 ± 2.2 μg/ml and 0.94 ± 0.62 h, respectively. The absorption half-life, alpha half-life, beta half-life, apparent steady-state volume of distribution, apparent total body clearance, and renal clearance were 0.56 ± 0.37 h, 0.78 ± 0.51 h, 10.56 ± 1.40 h, 0.85 ± 0.31 liters/kg, 129.2 ± 19.6 ml/min, and 53.3 ± 16.7 ml/min, respectively. Fleroxacin disposition in this patient population was similar to that in noninfected volunteers with normal renal function.
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U2 - 10.1128/AAC.34.5.922
DO - 10.1128/AAC.34.5.922
M3 - Article
C2 - 2113797
AN - SCOPUS:0025268536
VL - 34
SP - 922
EP - 923
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 5
ER -