Steady state dynamics of molecular motors reveals load dependent cooperativity

Saurav Talukdar, Shreyas Bhaban, Donatello Materassi, Murti Salapaka

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Intracellular transport of cargoes inside eukaryotic cells is primarily carried out by bio-mechanical machines called molecular motors. These motors facilitate the directed transfer of intracellular cargo to desired locations inside the cell. In vivo modes of transport often involve multiple agents, possibly of different types, teaming up to carry a common cargo. We analyze the stochastic dynamics of such cargos and prove that the probability distribution of various motor-motor configurations in an ensemble reaches a unique steady state. Existence of such a unique steady state indicates a degree of robustness of the system of multiple motors sharing a cargo. Analysis of the steady state distribution for an ensemble of two kinesin motors for varying load forces reveals a degree of cooperativity between the motors, where configurations that have the two motors clustered together are favored for moderate loads. We further show that when subjected to high forces, such as those encountered due to obstacles along the path of travel, motors preferably adopt a configuration that facilitates high probability of regaining motion once the obstacle is removed. Simulation results of the steady state distribution of a two motor ensemble for low, moderate and high load forces are presented, which corroborate analytical studies.

Original languageEnglish (US)
Title of host publication2016 IEEE 55th Conference on Decision and Control, CDC 2016
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages3356-3362
Number of pages7
ISBN (Electronic)9781509018376
DOIs
StatePublished - Dec 27 2016
Event55th IEEE Conference on Decision and Control, CDC 2016 - Las Vegas, United States
Duration: Dec 12 2016Dec 14 2016

Publication series

Name2016 IEEE 55th Conference on Decision and Control, CDC 2016

Other

Other55th IEEE Conference on Decision and Control, CDC 2016
CountryUnited States
CityLas Vegas
Period12/12/1612/14/16

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