Status of Drug Discovery in Wetlands Through a Lens of Bioprospecting for New Antimicrobials Being Produced by Microorganisms

Purpose of Review: The current review focuses on opportunities for new areas and new methods to isolate microorganisms from soil that could lead to new antimicrobial compounds. Recent Findings: Ongoing investigation of wetland microbial communities is vital for identifying novel antibiotics to combat the escalating threat of AMR. Exploring uncultured bacteria in soil has also led to promising compounds like teixobactin, which is effective against drug-resistant bacteria. Summary: Bioprospecting for new antimicrobials in wetland environments that focus on previously unculturable bacteria is an emerging field of study. The need for new antimicrobials demands innovative approaches to discovery, such as the Tiny Earth project, and a collaborative focus, such as the One Health Initiative.