Statins are a widely prescribed class of medications that inhibit similar pathways as the anti-resorptive bisphosphonate drugs. Statins target the mevalonate pathway by blocking HMG-CoA reductase. Several recent meta-analyses concluded statins are osteo-protective in the general population. Here we present current literature exploring the mechanisms underlying the putative osteoprotective effects of statins. We also review recent clinical studies, ranging from observational cohort studies to randomized clinical trials, testing the effect of statins on bone health in various populations.
|Translated title of the contribution||Statins and bone health: A mini review|
|Number of pages||5|
|Journal||Actualizaciones en Osteologia|
|State||Published - Jan 1 2018|
Bibliographical noteFunding Information:
This study received support from: The Department of Education, NIDILRR (90SI5015-01-00 LRM and JC) and the NIH (R01 AR064793-01A1 RABand LRM and HD056721 to LRM). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
- Bone loss
- Fracture healing