Statin myopathy: A common dilemma not reflected in clinical trials

Genaro Fernandez, Erica S. Spatz, Charles Jablecki, Paul S. Phillips

Research output: Contribution to journalReview articlepeer-review

185 Scopus citations


Although statins are remarkably effective, they are still underprescribed because of concerns about muscle toxicity. We review the aspects of statin myopathy that are important to the primary care physician and provide a guide for evaluating patients on statins who present with muscle complaints. We outline the differential diagnosis, the risks and benefits of statin therapy in patients with possible toxicity, and the subsequent treatment options.

Original languageEnglish (US)
Pages (from-to)393-403
Number of pages11
JournalCleveland Clinic journal of medicine
Issue number6
StatePublished - Jun 2011


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