State-Dependent Changes in Brain Glycogen Metabolism

Mauro DiNuzzo; Anne B. Walls; Gülin Öz; Elizabeth R. Seaquist; Helle S. Waagepetersen; Lasse K. Bak; Maiken Nedergaard; Arne Schousboe

doi:10.1007/978-3-030-27480-1_9

State-Dependent Changes in Brain Glycogen Metabolism

Mauro DiNuzzo, Anne B. Walls, Gülin Öz, Elizabeth R. Seaquist, Helle S. Waagepetersen, Lasse K. Bak, Maiken Nedergaard, Arne Schousboe

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

A fundamental understanding of glycogen structure, concentration, polydispersity and turnover is critical to qualify the role of glycogen in the brain. These molecular and metabolic features are under the control of neuronal activity through the interdependent action of neuromodulatory tone, ionic homeostasis and availability of metabolic substrates, all variables that concur to define the state of the system. In this chapter, we briefly describe how glycogen responds to selected behavioral, nutritional, environmental, hormonal, developmental and pathological conditions. We argue that interpreting glycogen metabolism through the lens of brain state is an effective approach to establish the relevance of energetics in connecting molecular and cellular neurophysiology to behavior.

Original language	English (US)
Title of host publication	Advances in Neurobiology
Publisher	Springer New York LLC
Pages	269-309
Number of pages	41
Volume	23
DOIs	https://doi.org/10.1007/978-3-030-27480-1_9
State	Published - Jan 1 2019

Publication series

Name	Advances in Neurobiology
Volume	23
ISSN (Print)	2190-5215
ISSN (Electronic)	2190-5223

Keywords

Astrocyte-neuron interactions
Brain state
Glycogen β-particle
Ion homeostasis
Metabolic compartmentation

PubMed: MeSH publication types

Journal Article
Review

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10.1007/978-3-030-27480-1_9

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State-Dependent Changes in Brain Glycogen Metabolism. / DiNuzzo, Mauro; Walls, Anne B.; Öz, Gülin ; Seaquist, Elizabeth R.; Waagepetersen, Helle S.; Bak, Lasse K.; Nedergaard, Maiken; Schousboe, Arne.

Advances in Neurobiology. Vol. 23 Springer New York LLC, 2019. p. 269-309 (Advances in Neurobiology; Vol. 23).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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AU - Walls, Anne B.

AU - Öz, Gülin

AU - Seaquist, Elizabeth R.

AU - Waagepetersen, Helle S.

AU - Bak, Lasse K.

AU - Nedergaard, Maiken

AU - Schousboe, Arne

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N2 - A fundamental understanding of glycogen structure, concentration, polydispersity and turnover is critical to qualify the role of glycogen in the brain. These molecular and metabolic features are under the control of neuronal activity through the interdependent action of neuromodulatory tone, ionic homeostasis and availability of metabolic substrates, all variables that concur to define the state of the system. In this chapter, we briefly describe how glycogen responds to selected behavioral, nutritional, environmental, hormonal, developmental and pathological conditions. We argue that interpreting glycogen metabolism through the lens of brain state is an effective approach to establish the relevance of energetics in connecting molecular and cellular neurophysiology to behavior.

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KW - Astrocyte-neuron interactions

KW - Brain state

KW - Glycogen β-particle

KW - Ion homeostasis

KW - Metabolic compartmentation

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State-Dependent Changes in Brain Glycogen Metabolism

Abstract

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Keywords

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