State-Dependent Changes in Brain Glycogen Metabolism

Mauro DiNuzzo, Anne B. Walls, Gülin Öz, Elizabeth R. Seaquist, Helle S. Waagepetersen, Lasse K. Bak, Maiken Nedergaard, Arne Schousboe

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

A fundamental understanding of glycogen structure, concentration, polydispersity and turnover is critical to qualify the role of glycogen in the brain. These molecular and metabolic features are under the control of neuronal activity through the interdependent action of neuromodulatory tone, ionic homeostasis and availability of metabolic substrates, all variables that concur to define the state of the system. In this chapter, we briefly describe how glycogen responds to selected behavioral, nutritional, environmental, hormonal, developmental and pathological conditions. We argue that interpreting glycogen metabolism through the lens of brain state is an effective approach to establish the relevance of energetics in connecting molecular and cellular neurophysiology to behavior.

Original languageEnglish (US)
Title of host publicationAdvances in Neurobiology
PublisherSpringer New York LLC
Pages269-309
Number of pages41
Volume23
DOIs
StatePublished - Jan 1 2019

Publication series

NameAdvances in Neurobiology
Volume23
ISSN (Print)2190-5215
ISSN (Electronic)2190-5223

Keywords

  • Astrocyte-neuron interactions
  • Brain state
  • Glycogen β-particle
  • Ion homeostasis
  • Metabolic compartmentation

PubMed: MeSH publication types

  • Journal Article
  • Review

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