State-Dependent Changes in Brain Glycogen Metabolism

Mauro DiNuzzo, Anne B. Walls, Gülin Öz, Elizabeth R. Seaquist, Helle S. Waagepetersen, Lasse K. Bak, Maiken Nedergaard, Arne Schousboe

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations


A fundamental understanding of glycogen structure, concentration, polydispersity and turnover is critical to qualify the role of glycogen in the brain. These molecular and metabolic features are under the control of neuronal activity through the interdependent action of neuromodulatory tone, ionic homeostasis and availability of metabolic substrates, all variables that concur to define the state of the system. In this chapter, we briefly describe how glycogen responds to selected behavioral, nutritional, environmental, hormonal, developmental and pathological conditions. We argue that interpreting glycogen metabolism through the lens of brain state is an effective approach to establish the relevance of energetics in connecting molecular and cellular neurophysiology to behavior.

Original languageEnglish (US)
Title of host publicationAdvances in Neurobiology
PublisherSpringer New York LLC
Number of pages41
StatePublished - 2019

Publication series

NameAdvances in neurobiology
PublisherSpringer Publishing Company
ISSN (Print)2190-5215

Bibliographical note

Funding Information:
This project has received funding from the European Union?s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 701635. The content is solely the responsibility of the authors and does not necessarily represent the official views of the European Union. Competing interests: The authors have declared that no competing interests exist.

Publisher Copyright:
© Springer Nature Switzerland AG 2019.


  • Astrocyte-neuron interactions
  • Brain state
  • Glycogen β-particle
  • Ion homeostasis
  • Metabolic compartmentation
  • Energy Metabolism
  • Neurons/metabolism
  • Brain/cytology
  • Glycogen/chemistry

PubMed: MeSH publication types

  • Review
  • Journal Article


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