A fundamental understanding of glycogen structure, concentration, polydispersity and turnover is critical to qualify the role of glycogen in the brain. These molecular and metabolic features are under the control of neuronal activity through the interdependent action of neuromodulatory tone, ionic homeostasis and availability of metabolic substrates, all variables that concur to define the state of the system. In this chapter, we briefly describe how glycogen responds to selected behavioral, nutritional, environmental, hormonal, developmental and pathological conditions. We argue that interpreting glycogen metabolism through the lens of brain state is an effective approach to establish the relevance of energetics in connecting molecular and cellular neurophysiology to behavior.
|Original language||English (US)|
|Title of host publication||Advances in Neurobiology|
|Publisher||Springer New York LLC|
|Number of pages||41|
|State||Published - 2019|
|Name||Advances in neurobiology|
|Publisher||Springer Publishing Company|
Bibliographical noteFunding Information:
This project has received funding from the European Union?s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 701635. The content is solely the responsibility of the authors and does not necessarily represent the official views of the European Union. Competing interests: The authors have declared that no competing interests exist.
© Springer Nature Switzerland AG 2019.
- Astrocyte-neuron interactions
- Brain state
- Glycogen β-particle
- Ion homeostasis
- Metabolic compartmentation
- Energy Metabolism
PubMed: MeSH publication types
- Journal Article