State-Dependent Changes in Brain Glycogen Metabolism

Mauro DiNuzzo; Anne B. Walls; Gülin Öz; Elizabeth R. Seaquist; Helle S. Waagepetersen; Lasse K. Bak; Maiken Nedergaard; Arne Schousboe

doi:10.1007/978-3-030-27480-1_9

State-Dependent Changes in Brain Glycogen Metabolism

Mauro DiNuzzo, Anne B. Walls, Gülin Öz, Elizabeth R. Seaquist, Helle S. Waagepetersen, Lasse K. Bak, Maiken Nedergaard, Arne Schousboe

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

A fundamental understanding of glycogen structure, concentration, polydispersity and turnover is critical to qualify the role of glycogen in the brain. These molecular and metabolic features are under the control of neuronal activity through the interdependent action of neuromodulatory tone, ionic homeostasis and availability of metabolic substrates, all variables that concur to define the state of the system. In this chapter, we briefly describe how glycogen responds to selected behavioral, nutritional, environmental, hormonal, developmental and pathological conditions. We argue that interpreting glycogen metabolism through the lens of brain state is an effective approach to establish the relevance of energetics in connecting molecular and cellular neurophysiology to behavior.

Original language	English (US)
Title of host publication	Advances in Neurobiology
Publisher	Springer New York LLC
Pages	269-309
Number of pages	41
Volume	23
DOIs	https://doi.org/10.1007/978-3-030-27480-1_9
State	Published - 2019

Publication series

Name	Advances in neurobiology
Publisher	Springer Publishing Company
ISSN (Print)	2190-5215

Bibliographical note

Funding Information:
This project has received funding from the European Union?s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 701635. The content is solely the responsibility of the authors and does not necessarily represent the official views of the European Union. Competing interests: The authors have declared that no competing interests exist.

Publisher Copyright:
© Springer Nature Switzerland AG 2019.

Keywords

Astrocyte-neuron interactions
Brain state
Glycogen β-particle
Ion homeostasis
Metabolic compartmentation
Energy Metabolism
Neurons/metabolism
Brain/cytology
Glycogen/chemistry

PubMed: MeSH publication types

Review
Journal Article

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10.1007/978-3-030-27480-1_9

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title = "State-Dependent Changes in Brain Glycogen Metabolism",

abstract = "A fundamental understanding of glycogen structure, concentration, polydispersity and turnover is critical to qualify the role of glycogen in the brain. These molecular and metabolic features are under the control of neuronal activity through the interdependent action of neuromodulatory tone, ionic homeostasis and availability of metabolic substrates, all variables that concur to define the state of the system. In this chapter, we briefly describe how glycogen responds to selected behavioral, nutritional, environmental, hormonal, developmental and pathological conditions. We argue that interpreting glycogen metabolism through the lens of brain state is an effective approach to establish the relevance of energetics in connecting molecular and cellular neurophysiology to behavior.",

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author = "Mauro DiNuzzo and Walls, {Anne B.} and G{\"u}lin {\"O}z and Seaquist, {Elizabeth R.} and Waagepetersen, {Helle S.} and Bak, {Lasse K.} and Maiken Nedergaard and Arne Schousboe",

note = "Funding Information: This project has received funding from the European Union?s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 701635. The content is solely the responsibility of the authors and does not necessarily represent the official views of the European Union. Competing interests: The authors have declared that no competing interests exist. Publisher Copyright: {\textcopyright} Springer Nature Switzerland AG 2019.",

year = "2019",

doi = "10.1007/978-3-030-27480-1_9",

language = "English (US)",

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AU - DiNuzzo, Mauro

AU - Walls, Anne B.

AU - Öz, Gülin

AU - Seaquist, Elizabeth R.

AU - Waagepetersen, Helle S.

AU - Bak, Lasse K.

AU - Nedergaard, Maiken

AU - Schousboe, Arne

N1 - Funding Information: This project has received funding from the European Union?s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 701635. The content is solely the responsibility of the authors and does not necessarily represent the official views of the European Union. Competing interests: The authors have declared that no competing interests exist. Publisher Copyright: © Springer Nature Switzerland AG 2019.

PY - 2019

Y1 - 2019

N2 - A fundamental understanding of glycogen structure, concentration, polydispersity and turnover is critical to qualify the role of glycogen in the brain. These molecular and metabolic features are under the control of neuronal activity through the interdependent action of neuromodulatory tone, ionic homeostasis and availability of metabolic substrates, all variables that concur to define the state of the system. In this chapter, we briefly describe how glycogen responds to selected behavioral, nutritional, environmental, hormonal, developmental and pathological conditions. We argue that interpreting glycogen metabolism through the lens of brain state is an effective approach to establish the relevance of energetics in connecting molecular and cellular neurophysiology to behavior.

AB - A fundamental understanding of glycogen structure, concentration, polydispersity and turnover is critical to qualify the role of glycogen in the brain. These molecular and metabolic features are under the control of neuronal activity through the interdependent action of neuromodulatory tone, ionic homeostasis and availability of metabolic substrates, all variables that concur to define the state of the system. In this chapter, we briefly describe how glycogen responds to selected behavioral, nutritional, environmental, hormonal, developmental and pathological conditions. We argue that interpreting glycogen metabolism through the lens of brain state is an effective approach to establish the relevance of energetics in connecting molecular and cellular neurophysiology to behavior.

KW - Astrocyte-neuron interactions

KW - Brain state

KW - Glycogen β-particle

KW - Ion homeostasis

KW - Metabolic compartmentation

KW - Energy Metabolism

KW - Neurons/metabolism

KW - Brain/cytology

KW - Glycogen/chemistry

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M3 - Chapter

C2 - 31667812

AN - SCOPUS:85074388613

VL - 23

T3 - Advances in neurobiology

SP - 269

EP - 309

BT - Advances in Neurobiology

PB - Springer New York LLC

ER -

State-Dependent Changes in Brain Glycogen Metabolism

Abstract

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Keywords

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