STAT5 plays a critical role in the development and function of many cell types. Here, we review the role of STAT5 in the development of T lymphocytes in the thymus and its subsequent role in the differentiation of distinct CD4+ helper and regulatory T-cell subsets.
Bibliographical noteFunding Information:
DLO is funded by a National Institutes of Health (NIH) T32 fellowship (T32 AI 007313). MAF is supported by grants from the NIH (R01 AI113138, R01 CA151845, R01 CA154998, and R01 CA185062).
© 2017 Owen DL and Farrar MA.
Copyright 2018 Elsevier B.V., All rights reserved.
- T-cell development
- T-cell function