Staphylococcus aureus Endocarditis: Combined Therapy With Vancomycin and Rifampin

R. J. Faville; D. E. Zaske; E. L. Kaplan; K. Crossley; L. D. Sabath; P. G. Quie

doi:10.1001/jama.1978.03290180037019

Staphylococcus aureus Endocarditis: Combined Therapy With Vancomycin and Rifampin

R. J. Faville, D. E. Zaske, E. L. Kaplan, K. Crossley, L. D. Sabath, P. G. Quie

Medicine - Veteran's Administration Medical Center

Research output: Contribution to journal › Article › peer-review

131 Scopus citations

Abstract

Two children with persistent bacteremia and endocarditis due to Staphylococcus aureus failed to respond to vancomycin therapy, even though serum levels greatly exceeded the inhibitory concentrations. The Staphylococcus from one patient was resistant to methicillin; the other patient had a penicillin hypersensitivity. There was a wide disparity between the minimum inhibitory and the minimum bactericidal concentrations of vancomycin. Striking clinical and laboratory evidence of improvement was demonstrated with the addition of rifampin therapy. (JAMA 240:1963-1965, 1978).

Original language	English (US)
Pages (from-to)	1963-1965
Number of pages	3
Journal	JAMA: The Journal of the American Medical Association
Volume	240
Issue number	18
DOIs	https://doi.org/10.1001/jama.1978.03290180037019
State	Published - Oct 27 1978

Publisher link

10.1001/jama.1978.03290180037019

Find It

Find It at U of M Libraries

Cite this

@article{341a616137444f14acc659c31a841c32,

title = "Staphylococcus aureus Endocarditis: Combined Therapy With Vancomycin and Rifampin",

abstract = "Two children with persistent bacteremia and endocarditis due to Staphylococcus aureus failed to respond to vancomycin therapy, even though serum levels greatly exceeded the inhibitory concentrations. The Staphylococcus from one patient was resistant to methicillin; the other patient had a penicillin hypersensitivity. There was a wide disparity between the minimum inhibitory and the minimum bactericidal concentrations of vancomycin. Striking clinical and laboratory evidence of improvement was demonstrated with the addition of rifampin therapy. (JAMA 240:1963-1965, 1978).",

author = "Faville, {R. J.} and Zaske, {D. E.} and Kaplan, {E. L.} and K. Crossley and Sabath, {L. D.} and Quie, {P. G.}",

year = "1978",

month = oct,

day = "27",

doi = "10.1001/jama.1978.03290180037019",

language = "English (US)",

volume = "240",

pages = "1963--1965",

journal = "JAMA: The Journal of the American Medical Association",

issn = "0098-7484",

publisher = "American Medical Association",

number = "18",

}

TY - JOUR

T1 - Staphylococcus aureus Endocarditis

T2 - Combined Therapy With Vancomycin and Rifampin

AU - Faville, R. J.

AU - Zaske, D. E.

AU - Kaplan, E. L.

AU - Crossley, K.

AU - Sabath, L. D.

AU - Quie, P. G.

PY - 1978/10/27

Y1 - 1978/10/27

N2 - Two children with persistent bacteremia and endocarditis due to Staphylococcus aureus failed to respond to vancomycin therapy, even though serum levels greatly exceeded the inhibitory concentrations. The Staphylococcus from one patient was resistant to methicillin; the other patient had a penicillin hypersensitivity. There was a wide disparity between the minimum inhibitory and the minimum bactericidal concentrations of vancomycin. Striking clinical and laboratory evidence of improvement was demonstrated with the addition of rifampin therapy. (JAMA 240:1963-1965, 1978).

AB - Two children with persistent bacteremia and endocarditis due to Staphylococcus aureus failed to respond to vancomycin therapy, even though serum levels greatly exceeded the inhibitory concentrations. The Staphylococcus from one patient was resistant to methicillin; the other patient had a penicillin hypersensitivity. There was a wide disparity between the minimum inhibitory and the minimum bactericidal concentrations of vancomycin. Striking clinical and laboratory evidence of improvement was demonstrated with the addition of rifampin therapy. (JAMA 240:1963-1965, 1978).

UR - http://www.scopus.com/inward/record.url?scp=0018251044&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018251044&partnerID=8YFLogxK

U2 - 10.1001/jama.1978.03290180037019

DO - 10.1001/jama.1978.03290180037019

M3 - Article

C2 - 249793

AN - SCOPUS:0018251044

SN - 0098-7484

VL - 240

SP - 1963

EP - 1965

JO - JAMA: The Journal of the American Medical Association

JF - JAMA: The Journal of the American Medical Association

IS - 18

ER -

Staphylococcus aureus Endocarditis: Combined Therapy With Vancomycin and Rifampin

Abstract

Publisher link

Find It

Other files and links

Fingerprint

Cite this