Staphylococcus aureus Endocarditis: Combined Therapy With Vancomycin and Rifampin

Ralph J. Faville, Darwin E. Zaske, Edward L. Kaplan, Kent Crossley, L. D. Sabath, Paul G. Quie

Research output: Contribution to journalArticlepeer-review


Two children with persistent bacteremia and endocarditis due to Staphylococcus aureus failed to respond to vancomycin therapy, even though serum levels greatly exceeded the inhibitory concentrations. The Staphylococcus from one patient was resistant to methicillin; the other patient had a penicillin hypersensitivity. There was a wide disparity between the minimum inhibitory and the minimum bactericidal concentrations of vancomycin. Striking clinical and laboratory evidence of improvement was demonstrated with the addition of rifampin therapy. (JAMA 240:1963-1965, 1978).

Original languageEnglish (US)
Pages (from-to)1963-1965
Number of pages3
JournalJAMA: The Journal of the American Medical Association
Issue number18
StatePublished - Oct 27 1978


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