Staphylococcus aureus endocarditis. Combined therapy with vancomycin and rifampin.

R. J. Jr Faville, D. E. Zaske, E. L. Kaplan, K. Crossley, L. D. Sabath, P. G. Quie

Research output: Contribution to journalArticlepeer-review


Two children with persistent bacteremia and endocarditis due to Staphylococcus aureus failed to respond to vancomycin therapy, even though serum levels greatly exceeded the inhibitory concentrations. The Staphylococcus from one patient was resistant to methicillin; the other patient had a penicillin hypersensitivity. There was a wide disparity between the minimum inhibitory and the minimum bactericidal concentrations of vancomycin. Striking clinical and laboratory evidence of improvement was demonstrated with the addition of rifampin therapy.
Original languageUndefined/Unknown
Pages (from-to)1963-1965
Number of pages3
Issue number18
StatePublished - 1978


  • Blood/mi [Microbiology]
  • Child, Preschool
  • Drug Therapy, Combination
  • Endocarditis, Bacterial/dt [Drug Therapy]
  • Female
  • Humans
  • Infant
  • Male
  • Methicillin/pd [Pharmacology]
  • Penicillin Resistance
  • Rifampin/ad [Administration & Dosage]
  • Sepsis/dt [Drug Therapy]
  • Staphylococcal Infections/dt [Drug Therapy]
  • Staphylococcus aureus/de [Drug Effects]
  • Vancomycin/ad [Administration & Dosage]

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