Staphylococcus aureus endocarditis. Combined therapy with vancomycin and rifampin.

R. J. Jr Faville, D. E. Zaske, E. L. Kaplan, K. Crossley, L. D. Sabath, P. G. Quie

Research output: Contribution to journalArticle

Abstract

Two children with persistent bacteremia and endocarditis due to Staphylococcus aureus failed to respond to vancomycin therapy, even though serum levels greatly exceeded the inhibitory concentrations. The Staphylococcus from one patient was resistant to methicillin; the other patient had a penicillin hypersensitivity. There was a wide disparity between the minimum inhibitory and the minimum bactericidal concentrations of vancomycin. Striking clinical and laboratory evidence of improvement was demonstrated with the addition of rifampin therapy.
Original languageUndefined/Unknown
Pages (from-to)1963-1965
Number of pages3
JournalJAMA
Volume240
Issue number18
StatePublished - 1978

Keywords

  • Blood/mi [Microbiology]
  • Child, Preschool
  • Drug Therapy, Combination
  • Endocarditis, Bacterial/dt [Drug Therapy]
  • Female
  • Humans
  • Infant
  • Male
  • Methicillin/pd [Pharmacology]
  • Penicillin Resistance
  • Rifampin/ad [Administration & Dosage]
  • Sepsis/dt [Drug Therapy]
  • Staphylococcal Infections/dt [Drug Therapy]
  • Staphylococcus aureus/de [Drug Effects]
  • Vancomycin/ad [Administration & Dosage]

Cite this

Faville, R. J. J., Zaske, D. E., Kaplan, E. L., Crossley, K., Sabath, L. D., & Quie, P. G. (1978). Staphylococcus aureus endocarditis. Combined therapy with vancomycin and rifampin. JAMA, 240(18), 1963-1965.

Staphylococcus aureus endocarditis. Combined therapy with vancomycin and rifampin. / Faville, R. J. Jr; Zaske, D. E.; Kaplan, E. L.; Crossley, K.; Sabath, L. D.; Quie, P. G.

In: JAMA, Vol. 240, No. 18, 1978, p. 1963-1965.

Research output: Contribution to journalArticle

Faville, RJJ, Zaske, DE, Kaplan, EL, Crossley, K, Sabath, LD & Quie, PG 1978, 'Staphylococcus aureus endocarditis. Combined therapy with vancomycin and rifampin.', JAMA, vol. 240, no. 18, pp. 1963-1965.
Faville RJJ, Zaske DE, Kaplan EL, Crossley K, Sabath LD, Quie PG. Staphylococcus aureus endocarditis. Combined therapy with vancomycin and rifampin. JAMA. 1978;240(18):1963-1965.
Faville, R. J. Jr ; Zaske, D. E. ; Kaplan, E. L. ; Crossley, K. ; Sabath, L. D. ; Quie, P. G. / Staphylococcus aureus endocarditis. Combined therapy with vancomycin and rifampin. In: JAMA. 1978 ; Vol. 240, No. 18. pp. 1963-1965.
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abstract = "Two children with persistent bacteremia and endocarditis due to Staphylococcus aureus failed to respond to vancomycin therapy, even though serum levels greatly exceeded the inhibitory concentrations. The Staphylococcus from one patient was resistant to methicillin; the other patient had a penicillin hypersensitivity. There was a wide disparity between the minimum inhibitory and the minimum bactericidal concentrations of vancomycin. Striking clinical and laboratory evidence of improvement was demonstrated with the addition of rifampin therapy.",
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AU - Faville, R. J. Jr

AU - Zaske, D. E.

AU - Kaplan, E. L.

AU - Crossley, K.

AU - Sabath, L. D.

AU - Quie, P. G.

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AB - Two children with persistent bacteremia and endocarditis due to Staphylococcus aureus failed to respond to vancomycin therapy, even though serum levels greatly exceeded the inhibitory concentrations. The Staphylococcus from one patient was resistant to methicillin; the other patient had a penicillin hypersensitivity. There was a wide disparity between the minimum inhibitory and the minimum bactericidal concentrations of vancomycin. Striking clinical and laboratory evidence of improvement was demonstrated with the addition of rifampin therapy.

KW - Blood/mi [Microbiology]

KW - Child, Preschool

KW - Drug Therapy, Combination

KW - Endocarditis, Bacterial/dt [Drug Therapy]

KW - Female

KW - Humans

KW - Infant

KW - Male

KW - Methicillin/pd [Pharmacology]

KW - Penicillin Resistance

KW - Rifampin/ad [Administration & Dosage]

KW - Sepsis/dt [Drug Therapy]

KW - Staphylococcal Infections/dt [Drug Therapy]

KW - Staphylococcus aureus/de [Drug Effects]

KW - Vancomycin/ad [Administration & Dosage]

M3 - Article

VL - 240

SP - 1963

EP - 1965

JO - JAMA - Journal of the American Medical Association

JF - JAMA - Journal of the American Medical Association

SN - 0098-7484

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ER -