Standard magnetic resonance-based measurements of the pi¡ATP rate do not index the rate of oxidative phosphorylation in cardiac and skeletal muscles

Arthur H.L. From, Kamil Ugurbil

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Magnetic resonance spectroscopybased magnetization transfer techniques (MT) are commonly used to assess the rate of oxidative (i.e., mitochondrial) ATP synthesis in intact tissues. Physiologically appropriate interpretation of MT rate data depends on accurate appraisal of the biochemical events that contribute to a specific MT rate measurement. The relative contributions of the specific enzymatic reactions that can contribute to a MT Pi¡ATP rate measurement are tissue dependent; nonrecognition of this fact can bias the interpretation of MT Pi¡ATP rate data. The complexities of MT-based measurements of mitochondrial ATP synthesis rates made in striated muscle and other tissues are reviewed, following which, the adverse impacts of erroneous Pi¡ATP rate data analyses on the physiological inferences presented in selected published studies of cardiac and skeletal muscle are considered.

Original languageEnglish (US)
Pages (from-to)C1-C11
JournalAmerican Journal of Physiology - Cell Physiology
Volume301
Issue number1
DOIs
StatePublished - Jul 1 2011

Keywords

  • Magnetization transfer
  • Oxidative ATP synthesis
  • Striated muscle

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