Stabilizing Biomacromolecules in Nontoxic Nano-Structured Materials

Michael M. Domach; Lynn M. Walker

doi:10.1016/j.jala.2010.01.002

Stabilizing Biomacromolecules in Nontoxic Nano-Structured Materials

Michael M. Domach
, Lynn M. Walker

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Increases in the use of protein-based pharmaceuticals require the development of cost-effective methods of storage and transport of sensitive biomolecules. In this article, we review the general problems of protein stabilization, aspects specific to antibodies, and a proposed method for protecting proteins based on nanostructured hydrogels. This review is not intended to be comprehensive, but instead to provide the reader with specific examples that capture some of the key challenges and opportunities of the field.

Original language	English (US)
Pages (from-to)	136-144
Number of pages	9
Journal	JALA - Journal of the Association for Laboratory Automation
Volume	15
Issue number	2
DOIs	https://doi.org/10.1016/j.jala.2010.01.002
State	Published - Apr 2010
Externally published	Yes

Bibliographical note

Funding Information:
Theresa LaFollette performed the protein aggregation studies and analysis; she acknowledges an NSF Graduate Fellowship for funding of her thesis work.

Keywords

antibodies
block copolymers
hydrogels
protein aggregation
protein stability

Publisher link

10.1016/j.jala.2010.01.002

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title = "Stabilizing Biomacromolecules in Nontoxic Nano-Structured Materials",

abstract = "Increases in the use of protein-based pharmaceuticals require the development of cost-effective methods of storage and transport of sensitive biomolecules. In this article, we review the general problems of protein stabilization, aspects specific to antibodies, and a proposed method for protecting proteins based on nanostructured hydrogels. This review is not intended to be comprehensive, but instead to provide the reader with specific examples that capture some of the key challenges and opportunities of the field.",

keywords = "antibodies, block copolymers, hydrogels, protein aggregation, protein stability",

author = "Domach, \{Michael M.\} and Walker, \{Lynn M.\}",

note = "Funding Information: Theresa LaFollette performed the protein aggregation studies and analysis; she acknowledges an NSF Graduate Fellowship for funding of her thesis work. ",

year = "2010",

month = apr,

doi = "10.1016/j.jala.2010.01.002",

language = "English (US)",

volume = "15",

pages = "136--144",

journal = "JALA - Journal of the Association for Laboratory Automation",

issn = "1535-5535",

publisher = "Association for Laboratory Automation",

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T1 - Stabilizing Biomacromolecules in Nontoxic Nano-Structured Materials

AU - Domach, Michael M.

AU - Walker, Lynn M.

N1 - Funding Information: Theresa LaFollette performed the protein aggregation studies and analysis; she acknowledges an NSF Graduate Fellowship for funding of her thesis work.

PY - 2010/4

Y1 - 2010/4

N2 - Increases in the use of protein-based pharmaceuticals require the development of cost-effective methods of storage and transport of sensitive biomolecules. In this article, we review the general problems of protein stabilization, aspects specific to antibodies, and a proposed method for protecting proteins based on nanostructured hydrogels. This review is not intended to be comprehensive, but instead to provide the reader with specific examples that capture some of the key challenges and opportunities of the field.

AB - Increases in the use of protein-based pharmaceuticals require the development of cost-effective methods of storage and transport of sensitive biomolecules. In this article, we review the general problems of protein stabilization, aspects specific to antibodies, and a proposed method for protecting proteins based on nanostructured hydrogels. This review is not intended to be comprehensive, but instead to provide the reader with specific examples that capture some of the key challenges and opportunities of the field.

KW - antibodies

KW - block copolymers

KW - hydrogels

KW - protein aggregation

KW - protein stability

UR - https://www.scopus.com/pages/publications/77649306835

UR - https://www.scopus.com/pages/publications/77649306835#tab=citedBy

U2 - 10.1016/j.jala.2010.01.002

DO - 10.1016/j.jala.2010.01.002

M3 - Review article

AN - SCOPUS:77649306835

SN - 1535-5535

VL - 15

SP - 136

EP - 144

JO - JALA - Journal of the Association for Laboratory Automation

JF - JALA - Journal of the Association for Laboratory Automation

IS - 2

ER -

Stabilizing Biomacromolecules in Nontoxic Nano-Structured Materials

Abstract

Bibliographical note

Keywords

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