Stabilizing Biomacromolecules in Nontoxic Nano-Structured Materials

Michael M. Domach, Lynn M. Walker

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Increases in the use of protein-based pharmaceuticals require the development of cost-effective methods of storage and transport of sensitive biomolecules. In this article, we review the general problems of protein stabilization, aspects specific to antibodies, and a proposed method for protecting proteins based on nanostructured hydrogels. This review is not intended to be comprehensive, but instead to provide the reader with specific examples that capture some of the key challenges and opportunities of the field.

Original languageEnglish (US)
Pages (from-to)136-144
Number of pages9
JournalJALA - Journal of the Association for Laboratory Automation
Volume15
Issue number2
DOIs
StatePublished - Apr 2010
Externally publishedYes

Bibliographical note

Funding Information:
Theresa LaFollette performed the protein aggregation studies and analysis; she acknowledges an NSF Graduate Fellowship for funding of her thesis work.

Keywords

  • antibodies
  • block copolymers
  • hydrogels
  • protein aggregation
  • protein stability

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