Stability of stereognosis after pediatric repetitive transcranial magnetic stimulation and constraint-induced movement therapy clinical trial

Tonya Rich; Jessica Cassidy; Jeremiah Menk; Ann Van Heest; Linda Krach; James Carey; Bernadette T. Gillick

doi:10.3109/17518423.2016.1139008

Stability of stereognosis after pediatric repetitive transcranial magnetic stimulation and constraint-induced movement therapy clinical trial

Tonya Rich, Jessica Cassidy, Jeremiah Menk, Ann Van Heest, Linda Krach, James Carey, Bernadette T. Gillick

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Objective: Poor sensibility affecting stereognosis, the ability to discriminate objects without visual input, can potentiate disuse of the paretic limb following stroke. The purpose of this study was to examine potential change in stereognosis after intervention. Methods: Stereognosis testing in a secondary subgroup of 10 children with hemiparesis and baseline stereognosis deficits (ages 11–16) after a 13-day clinical trial of real or sham repetitive transcranial magnetic stimulation (rTMS) and constraint-induced movement therapy (CIMT) is reported. All children received 10 h of CIMT while wearing a cast full-time. Results: Post-trial, 80% of participants from both intervention groups demonstrated improvement in stereognosis (95% CI: 44.4%–97.5%). Pre-trial to long-term follow-up (range: 21–57 months), 60% retained gains or improved (95% CI: 26.2%–87.8%). Between-group differences were not detected. Discussion: Children demonstrated stereognosis change following intervention. Research on this change and potential minimal clinically important differences are indicated.

Original language	English (US)
Pages (from-to)	169-172
Number of pages	4
Journal	Developmental Neurorehabilitation
Volume	20
Issue number	3
DOIs	https://doi.org/10.3109/17518423.2016.1139008
State	Published - Apr 3 2017

Bibliographical note

Funding Information:
This study is registered on the United States National Institutes of Health (NIH) clinicaltrials.gov (NCT01104064). This study was funded by NIH grant number 1 RC1HD063838-01, 1UL1RR033183-01 from the National Center for Research Resources and by grant number 8 UL1 TR000114-02 from the National Center for Advancing Translational Sciences of the National Institutes of Health to the University of Minnesota Clinical and Translational Science Institute (CTSI). The University of Minnesota Center for Magnetic Resonance Research funding supported the imaging work number P41 EB015894. This research was also supported by the Foundation for Physical Therapy Promotion of Doctoral Studies, the American Academy of Cerebral Palsy and Developmental Medicine Student and OrthoPediatrics Travel Awards University of Minnesota Leadership and Education in Neurodevelopmental Disabilities (LEND) and Minnesota?s Discovery, Research InnoVation Economy (MnDRIVE) fellowships.

Publisher Copyright:
© 2017 Taylor & Francis.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

Constraint-induced movement therapy
hemiparesis
non-invasive brain stimulation
pediatrics
stroke
transcranial magnetic stimulation

Publisher link

10.3109/17518423.2016.1139008

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490365

Find It

Find It at U of M Libraries

Cite this

@article{8b30665e11dd4239b1ffe0a8c3e0afc9,

title = "Stability of stereognosis after pediatric repetitive transcranial magnetic stimulation and constraint-induced movement therapy clinical trial",

abstract = "Objective: Poor sensibility affecting stereognosis, the ability to discriminate objects without visual input, can potentiate disuse of the paretic limb following stroke. The purpose of this study was to examine potential change in stereognosis after intervention. Methods: Stereognosis testing in a secondary subgroup of 10 children with hemiparesis and baseline stereognosis deficits (ages 11–16) after a 13-day clinical trial of real or sham repetitive transcranial magnetic stimulation (rTMS) and constraint-induced movement therapy (CIMT) is reported. All children received 10 h of CIMT while wearing a cast full-time. Results: Post-trial, 80% of participants from both intervention groups demonstrated improvement in stereognosis (95% CI: 44.4%–97.5%). Pre-trial to long-term follow-up (range: 21–57 months), 60% retained gains or improved (95% CI: 26.2%–87.8%). Between-group differences were not detected. Discussion: Children demonstrated stereognosis change following intervention. Research on this change and potential minimal clinically important differences are indicated.",

keywords = "Constraint-induced movement therapy, hemiparesis, non-invasive brain stimulation, pediatrics, stroke, transcranial magnetic stimulation",

author = "Tonya Rich and Jessica Cassidy and Jeremiah Menk and {Van Heest}, Ann and Linda Krach and James Carey and Gillick, {Bernadette T.}",

note = "Funding Information: This study is registered on the United States National Institutes of Health (NIH) clinicaltrials.gov (NCT01104064). This study was funded by NIH grant number 1 RC1HD063838-01, 1UL1RR033183-01 from the National Center for Research Resources and by grant number 8 UL1 TR000114-02 from the National Center for Advancing Translational Sciences of the National Institutes of Health to the University of Minnesota Clinical and Translational Science Institute (CTSI). The University of Minnesota Center for Magnetic Resonance Research funding supported the imaging work number P41 EB015894. This research was also supported by the Foundation for Physical Therapy Promotion of Doctoral Studies, the American Academy of Cerebral Palsy and Developmental Medicine Student and OrthoPediatrics Travel Awards University of Minnesota Leadership and Education in Neurodevelopmental Disabilities (LEND) and Minnesota?s Discovery, Research InnoVation Economy (MnDRIVE) fellowships. Publisher Copyright: {\textcopyright} 2017 Taylor & Francis. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2017",

month = apr,

day = "3",

doi = "10.3109/17518423.2016.1139008",

language = "English (US)",

volume = "20",

pages = "169--172",

journal = "Developmental Neurorehabilitation",

issn = "1751-8423",

publisher = "Informa Healthcare",

number = "3",

}

TY - JOUR

T1 - Stability of stereognosis after pediatric repetitive transcranial magnetic stimulation and constraint-induced movement therapy clinical trial

AU - Rich, Tonya

AU - Cassidy, Jessica

AU - Menk, Jeremiah

AU - Van Heest, Ann

AU - Krach, Linda

AU - Carey, James

AU - Gillick, Bernadette T.

N1 - Funding Information: This study is registered on the United States National Institutes of Health (NIH) clinicaltrials.gov (NCT01104064). This study was funded by NIH grant number 1 RC1HD063838-01, 1UL1RR033183-01 from the National Center for Research Resources and by grant number 8 UL1 TR000114-02 from the National Center for Advancing Translational Sciences of the National Institutes of Health to the University of Minnesota Clinical and Translational Science Institute (CTSI). The University of Minnesota Center for Magnetic Resonance Research funding supported the imaging work number P41 EB015894. This research was also supported by the Foundation for Physical Therapy Promotion of Doctoral Studies, the American Academy of Cerebral Palsy and Developmental Medicine Student and OrthoPediatrics Travel Awards University of Minnesota Leadership and Education in Neurodevelopmental Disabilities (LEND) and Minnesota?s Discovery, Research InnoVation Economy (MnDRIVE) fellowships. Publisher Copyright: © 2017 Taylor & Francis. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2017/4/3

Y1 - 2017/4/3

N2 - Objective: Poor sensibility affecting stereognosis, the ability to discriminate objects without visual input, can potentiate disuse of the paretic limb following stroke. The purpose of this study was to examine potential change in stereognosis after intervention. Methods: Stereognosis testing in a secondary subgroup of 10 children with hemiparesis and baseline stereognosis deficits (ages 11–16) after a 13-day clinical trial of real or sham repetitive transcranial magnetic stimulation (rTMS) and constraint-induced movement therapy (CIMT) is reported. All children received 10 h of CIMT while wearing a cast full-time. Results: Post-trial, 80% of participants from both intervention groups demonstrated improvement in stereognosis (95% CI: 44.4%–97.5%). Pre-trial to long-term follow-up (range: 21–57 months), 60% retained gains or improved (95% CI: 26.2%–87.8%). Between-group differences were not detected. Discussion: Children demonstrated stereognosis change following intervention. Research on this change and potential minimal clinically important differences are indicated.

AB - Objective: Poor sensibility affecting stereognosis, the ability to discriminate objects without visual input, can potentiate disuse of the paretic limb following stroke. The purpose of this study was to examine potential change in stereognosis after intervention. Methods: Stereognosis testing in a secondary subgroup of 10 children with hemiparesis and baseline stereognosis deficits (ages 11–16) after a 13-day clinical trial of real or sham repetitive transcranial magnetic stimulation (rTMS) and constraint-induced movement therapy (CIMT) is reported. All children received 10 h of CIMT while wearing a cast full-time. Results: Post-trial, 80% of participants from both intervention groups demonstrated improvement in stereognosis (95% CI: 44.4%–97.5%). Pre-trial to long-term follow-up (range: 21–57 months), 60% retained gains or improved (95% CI: 26.2%–87.8%). Between-group differences were not detected. Discussion: Children demonstrated stereognosis change following intervention. Research on this change and potential minimal clinically important differences are indicated.

KW - Constraint-induced movement therapy

KW - hemiparesis

KW - non-invasive brain stimulation

KW - pediatrics

KW - stroke

KW - transcranial magnetic stimulation

UR - http://www.scopus.com/inward/record.url?scp=84961212397&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961212397&partnerID=8YFLogxK

U2 - 10.3109/17518423.2016.1139008

DO - 10.3109/17518423.2016.1139008

M3 - Article

C2 - 26985568

AN - SCOPUS:84961212397

SN - 1751-8423

VL - 20

SP - 169

EP - 172

JO - Developmental Neurorehabilitation

JF - Developmental Neurorehabilitation

IS - 3

ER -

Stability of stereognosis after pediatric repetitive transcranial magnetic stimulation and constraint-induced movement therapy clinical trial

Abstract

Bibliographical note

Keywords

Publisher link

Find It

Other files and links

Fingerprint

Cite this