Stability of small mesoporous silica nanoparticles in biological media

Yu Shen Lin, Nardine Abadeer, Christy L. Haynes

Research output: Contribution to journalArticlepeer-review

120 Scopus citations

Abstract

In this work, sub-50 nm pegylated mesoporous silica nanoparticles prepared with hydrothermal treatment are shown to have long-term stability in various media at both room and physiological temperature. Compared to bare mesoporous silica nanoparticles, the highly pegylated mesoporous silica nanoparticles show significantly improved biocompatibility and decreased macrophage uptake, making these nanoparticles viable for in vivo stealth drug delivery applications.

Original languageEnglish (US)
Pages (from-to)532-534
Number of pages3
JournalChemical Communications
Volume47
Issue number1
DOIs
StatePublished - Jan 7 2011

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