Stability of isradipine in an extemporaneously compounded oral liquid

J. L. MacDonald, C. E. Johnson, P. Jacobson

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The stability of isradipine in an extemporaneously compounded oral liquid was studied. A suspension was prepared from the powder of commercially available 5-mg isradipine capsules and sufficient Simple Syrup, NF, to make a final volume of 50 mL. A control suspension was prepared from analytical- grade isradipine powder and Simple Syrup, NF. The final concentration of isradipine in both suspensions was 1 mg/mL. Three identical volumes of each suspension were stored in 2-oz amber glass prescription bottles, which were stored at 4 °C. Immediately after preparation and at 7, 16, 22, 28, and 35 days, samples were visually inspected and assayed in duplicate by high- performance liquid chromatography; the pH of the samples was also determined. At least 95% of the initial isradipine concentration remained throughout the study period in all samples of both suspensions. Color, odor, and pH did not change appreciably. Isradipine 1 mg/mL in an oral liquid compounded from Simple Syrup, NF, and powder from capsules was stable for at least 35 days in amber glass bottles at 4 °C.

Original languageEnglish (US)
Pages (from-to)2409-2411
Number of pages3
JournalAmerican Journal of Hospital Pharmacy
Volume51
Issue number19
DOIs
StatePublished - Jan 1 1994

Keywords

  • Compounding
  • Hypotensive agents
  • Incompatibilities
  • Isradipine
  • Stability
  • Storage
  • Sucrose
  • Suspensions
  • Tab lets
  • Vehicles

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