Stability evaluation of propolis topical bases for veterinary use

Luana d.Avila Farias, Camila Bugnotto Pereira, Gustavo Machado, Cleber Alberto Schmidt, Agueda Castagna De Vargas

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


This study aimed to evaluate and select different dermatological bases incorporated with propolis for veterinary use as well as to analyze the chemical compounds of the propolis hydroalcoholic extract by LC-MS/MS. Thus, formulations were submitted to accelerated stability tests under different temperatures and to mechanical stress, and evaluated for the appearance, color, odor, pH, viscosity, spreadability, and the mean size of the dispersed globules from the internal phase during a period of three months. The creamy gel formulation showed satisfactory results for all the evaluated items with an excellent capability to incorporate the hydroalcoholic extract of propolis associated to the maintenance of its physicochemical properties. The propolis used in this study had been shown to possess antibacterial and antifungal in vitro activity against the main microorganisms responsible for such diseases. Therefore, the propolis creamy gel described here could be a promising formulation for use in the veterinary medicine.

Original languageEnglish (US)
Pages (from-to)942-947
Number of pages6
JournalBrazilian Archives of Biology and Technology
Issue number6
StatePublished - Nov 2013
Externally publishedYes


  • Accelerated stability
  • Caffeic acid
  • Phytotherapic
  • Propolis


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