SRCI: An intron-containing yeast gene involved in sister chromatid segregation

David Cognetti, Dana Davis, Joy Sturtevant

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Analysis of a three-member gene family in the yeast Saccharomyces cerevisiae has allowed the discovery of a new gene that comprises two contiguous open reading frames previously annotated as YML034w and YML033w. The gene contains a small intron with two alternative 5′ splicing sites. It is specifically transcribed during G2/M in the cell cycle and after several hours of meiosis induction. Splicing of the mRNA is partially dependent on NAM8 but does not vary during meiosis or the cell cycle. Deletion of the gene induces a shortening of the anaphase and aggravates the phenotype of scc1 and esp1 conditional mutants, which suggests a direct role of the protein in sister chromatid separation.

Original languageEnglish (US)
Pages (from-to)43-54
Number of pages12
JournalYeast
Volume19
Issue number1
DOIs
StatePublished - Jan 31 2002

Keywords

  • Cell cycle
  • Mitosis meiosis
  • Saccharomyces cerevisiae
  • Sister chromatid
  • Splicing

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