Manipulating long DNA molecules has been a topic of longstanding interest at MicroTAS, typically driven by the need for new genomics technologies. This presentation addresses the other side of the coin, examining how nanofluidics enables precise tests of physical models for how semifiexible molecules like DNA behave when they are confined to small spaces. Nanofluidic genomics tools provide especially stringent tests of these physical models and have exposed important gaps in our understanding of DNA-wall electrostatic interactions.
|Original language||English (US)|
|Title of host publication||MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences|
|Publisher||Chemical and Biological Microsystems Society|
|Number of pages||2|
|State||Published - 2020|
|Event||24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online|
Duration: Oct 4 2020 → Oct 9 2020
|Name||MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences|
|Conference||24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020|
|Period||10/4/20 → 10/9/20|
Bibliographical noteFunding Information:
This work was supported by NIH R01-HG006851. I acknowledge contributions from my students Hui-Min Chuang, Aditya Bhandari, Guo-Kang Cheong, Damini Gupta and collaborators at Gothenburg University (Erik Werner, Daniel Odman and Bernhard Mehlig), Charles Doering (University of Michigan), and Jeff Reifenberger (BioNano Genomics). Aditya Bhandari prepared Figures 1 and 2.
© 2020 CBMS-0001