Squamous cell carcinoma of the lungs arising in recurrent respiratory papillomatosis

Dalia Hammoud, Boutros El Haddad

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Squamous papillomas of the lung are an uncommon feature of recurrent respiratory papillomatosis (RRP), occurring in fewer than 1% of cases. We describe an 18-year-old male patient with pulmonary papilloma who developed a fatal squamous cell carcinoma of the lung. Both benign papillomas and invasive carcinoma were positive for human papilloma virus subtype 6 and 11. These findings suggest that HPV 6 and 11 are correlated with malignant transformation in the setting of juvenile-onset recurrent respiratory papillomatosis even without tobacco or radiation exposure.

Original languageEnglish (US)
Pages (from-to)270-272
Number of pages3
JournalRespiratory Medicine CME
Issue number4
StatePublished - 2010
Externally publishedYes


  • HPV 6 and 11
  • Recurrent respiratory papillomatosis
  • Spontaneous malignant transformation
  • Squamous cell carcinoma of the lungs


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