Single-walled, nearly monodisperse, equilibrium vesicles form spontaneously when cholinergics such as choline chloride, acetylcholine chloride, calcium salt of phosphorylcholine chloride, or succinylcholine chloride, a muscle relaxant, are added to the solutions of sodium bis[2-ethylhexyl]sulfosuccinate (AOT). Partial phase diagrams mapping the stable vesicle region are presented for the systems AOT/water/choline chloride, AOT/water/acetylcholine chloride, AOT/water/phosphorylcholine chloride calcium salt, and AOT/water/succinylcholine chloride. The measured diameters for the vesicles made with these choline chloride compounds are 2000A °for acetylcholine chloride and 1000A °for choline chloride, succinylcholine chloride, and the calcium salt of phosphorylcholine chloride.
Bibliographical noteFunding Information:
This work was supported by National Science Foundation Grants PYIA-8351179 and CBT-8657444.