Spontaneous vesicles from aqueous solutions of aerosol OT and choline chloride compounds

A. Kamalakara Murthy, Eric W. Kaler, Joseph A.N. Zasadzinski

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21 Scopus citations


Single-walled, nearly monodisperse, equilibrium vesicles form spontaneously when cholinergics such as choline chloride, acetylcholine chloride, calcium salt of phosphorylcholine chloride, or succinylcholine chloride, a muscle relaxant, are added to the solutions of sodium bis[2-ethylhexyl]sulfosuccinate (AOT). Partial phase diagrams mapping the stable vesicle region are presented for the systems AOT/water/choline chloride, AOT/water/acetylcholine chloride, AOT/water/phosphorylcholine chloride calcium salt, and AOT/water/succinylcholine chloride. The measured diameters for the vesicles made with these choline chloride compounds are 2000A °for acetylcholine chloride and 1000A °for choline chloride, succinylcholine chloride, and the calcium salt of phosphorylcholine chloride.

Original languageEnglish (US)
Pages (from-to)598-600
Number of pages3
JournalJournal of Colloid And Interface Science
Issue number2
StatePublished - Sep 1991

Bibliographical note

Funding Information:
This work was supported by National Science Foundation Grants PYIA-8351179 and CBT-8657444.


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