Spontaneous vesicle formation in aqueous mixtures of single-tailed surfactants

Eric W. Kaler, A. Kamalakara Murthy, Beatriz E. Rodriguez, Joseph A.N. Zasadzinski

Research output: Contribution to journalArticlepeer-review

1144 Scopus citations


Spontaneous, single-walled, equilibrium vesicles can be prepared from aqueous mixtures of simple, commercially available, single-tailed cationic and anionic surfactants. Vesicle size, surface charge, or permeability can be readily adjusted by varying the ratio of anionic to cationic surfactant. Vesicle formation apparently results from the production of anion-cation surfactant pairs that then act as double-tailed zwitter-ionic surfactants. These vesicles are quite stable in comparison to conventional vesicles prepared by mechanical disruption of insoluble liquid crystalline dispersions.

Original languageEnglish (US)
Pages (from-to)1371-1374
Number of pages4
Issue number4924
StatePublished - Jan 1 1989


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