Spontaneous Spiking and Synaptic Depression Underlie Noradrenergic Control of Feed-Forward Inhibition

Sidney P. Kuo, Laurence O. Trussell

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Inhibitory interneurons across diverse brain regions commonly exhibit spontaneous spiking activity, even in the absence of external stimuli. It is not well understood how stimulus-evoked inhibition can be distinguished from background inhibition arising from spontaneous firing. We found that noradrenaline simultaneously reduced spontaneous inhibitory inputs and enhanced evoked inhibitory currents recorded from principal neurons of the mouse dorsal cochlear nucleus (DCN). Together, these effects produced a large increase in signal-to-noise ratio for stimulus-evoked inhibition. Surprisingly, the opposing effects on background and evoked currents could both be attributed to noradrenergic silencing of spontaneous spiking in glycinergic interneurons. During spontaneous firing, glycine release was decreased due to strong short-term depression. Elimination of background spiking relieved inhibitory synapses from depression and thereby enhanced stimulus-evoked inhibition. Our findings illustrate a simple yet powerful neuromodulatory mechanism to shift the balance between background and stimulus-evoked signals.

Original languageEnglish (US)
Pages (from-to)306-318
Number of pages13
JournalNeuron
Volume71
Issue number2
DOIs
StatePublished - Jul 28 2011
Externally publishedYes

Bibliographical note

Funding Information:
We are grateful to Pierre Apostolides and Drs. Hai Huang, Haining Zhong, and Craig Jahr for helpful discussions and to Elizabeth Brodeen-Kuo and Drs. Kevin Bender and John Williams for advice and suggestions on the manuscript. We thank Dr. Sascha du Lac for providing GIN and GlyT2-EGFP mice. This work was supported by NIH grants RO1DC004450 (L.O.T.) and F31DC010120 (S.P.K.).

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