Spontaneous slow potentials and spreading depression in amphibian retina

J. S. Olsen, R. F. Miller

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

In frog and mudpuppy eye cups perfused with low chloride solution, 2 types of slow potential phenomena were studied. One type, 'spontaneous slow potentials' (SSPs), appeared both in the dark and during light stimuli. The other type, the slow potential change (SPC) of spreading depression (SD), appeared at termination of long duration light stimuli. The SSPs were analyzed by depth profile studies, pharmacologic studies, and the use of potassium specific electrodes. Results indicated that SSPs may represent spontaneous d waves that travel across the retina. The SSPs are associated with potassium activity, and the main response is probably generated by Muller cells. Initiation and/or propagation appear to require chemically mediated synaptic transmission and impulse activity. Depth profile studies were also done of the SPC of SD induced by termination of long duration light stimuli. Results indicated that the SPC is not an exaggerated d wave. The SPC consists of 2 components, the second of which reverses more superficially than the d wave. The main SPC response is probably generated by Muller cells. Although impulse activity does not appear to be necessary for SD, it may contribute to this complex response.

Original languageEnglish (US)
Pages (from-to)452-467
Number of pages16
JournalJournal of neurophysiology
Volume40
Issue number4
StatePublished - Jan 1 1977

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