Spontaneous neural activity differences in posttraumatic stress disorder: A quantitative resting-state meta-analysis and fMRI validation

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14 Scopus citations

Abstract

Identifying the pathophysiology of posttraumatic stress disorder (PTSD) is a critical step toward reducing its debilitating impact. Spontaneous neural activity, measured at rest using various neuroimaging techniques (e.g., regional homogeneity [ReHo], amplitude of low frequency fluctuations [ALFF]), can provide insight about baseline neurobiological factors influencing sensory, cognitive, or behavioral processes associated with PTSD. The present study used activation likelihood estimation (ALE) to conduct the largest-to-date quantitative meta-analysis of spontaneous neural activity in PTSD, including 457 PTSD cases, 292 trauma-exposed controls (TECs), and 293 non-traumatized controls (NTCs) across 22 published studies. Five regions-of-interest (ROIs) were identified where activity differed between PTSD cases and controls: one when compared to all controls (left globus pallidus), two when compared to TECs (left inferior parietal lobule [IPL] and right lingual gyrus), and two when compared to NTCs (left amygdala and right caudate head). To corroborate these results, a second analysis was conducted using resting-state functional magnetic resonance imaging on an independent sample of 205 previously-deployed US military veterans. In this analysis, converging evidence from ReHo and ALFF showed that spontaneous neural activity in the left IPL alone was positively correlated with PTSD symptom severity. This result is consistent with theoretical accounts that link left IPL activity with PTSD-relevant processes such as processing of emotional stimuli (e.g., fearful faces) and the extent that attention is captured by salient autobiographical memories. By modeling the neurobiological correlates of PTSD, we can increase our understanding of this debilitating disorder and guide the development of future clinical innovations.

Original languageEnglish (US)
Pages (from-to)837-850
Number of pages14
JournalHuman Brain Mapping
Volume39
Issue number2
DOIs
StatePublished - Feb 1 2018

Bibliographical note

Funding Information:
We thank Dr. Michael Armstrong, Dr. Kelvin Lim, and Dr. Nicholas Davenport for their contributions to this project. This research is the result of work supported with resources and the use of facilities at the MVAHCS. Funding support was provided by the Congressionally Directed Medical Research Program (W81XWH-08–2–0038: PI-Sponheim), the Department of Veterans Affairs, Rehabilitation R&D Program (I01RX000622: PI-Sponheim; 1IK1RX002325: PI-Disner), and the National Science Foundation (Graduate Research Fellowship 00039202: PI-Marquardt). The contents do not represent the views of the U.S. Department of Veterans Affairs, the National Science Foundation, or the United States Government. The authors declared that they had no conflicts of interest with respect to their authorship or the publication of this article.

Keywords

  • amygdala
  • globus pallidus
  • magnetic resonance imaging
  • neuroimaging
  • occipital lobe
  • parietal lobe
  • post-traumatic stress disorder
  • rest
  • veterans

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