TY - JOUR
T1 - Spontaneous acute erythroblastic leukaemia (AML-M6Er) in a dog
AU - Tomiyasu, H.
AU - Fujino, Y.
AU - Takahashi, M.
AU - Ohno, K.
AU - Tsujimoto, H.
PY - 2011/8
Y1 - 2011/8
N2 - A five-year-old golden retriever was presented with anaemia, thrombocytopenia, anorexia and lethargy. Peripheral blood cytology showed abnormal cells similar to proerythroblasts with multiple nucleoli and strongly basophilic cytoplasm. Bone marrow cytopathology revealed that the blast cells accounted for more than 80% of all nucleated cells (ANC). These blast cells were confirmed as erythroblastic cells by cytochemistry, polymerase chain reaction for genetic clonality assessment of IgH and TCRf, flow cytometry, and transmission electron microscopy. Based on these observations, the dog was diagnosed with acute erythroblastic leukaemia (AML-M6Er). Chemotherapy with cytarabine commenced on day 7 after initial presentation, but the dog died 2 days later. This is the first report of spontaneous AML-M6Er in a dog.
AB - A five-year-old golden retriever was presented with anaemia, thrombocytopenia, anorexia and lethargy. Peripheral blood cytology showed abnormal cells similar to proerythroblasts with multiple nucleoli and strongly basophilic cytoplasm. Bone marrow cytopathology revealed that the blast cells accounted for more than 80% of all nucleated cells (ANC). These blast cells were confirmed as erythroblastic cells by cytochemistry, polymerase chain reaction for genetic clonality assessment of IgH and TCRf, flow cytometry, and transmission electron microscopy. Based on these observations, the dog was diagnosed with acute erythroblastic leukaemia (AML-M6Er). Chemotherapy with cytarabine commenced on day 7 after initial presentation, but the dog died 2 days later. This is the first report of spontaneous AML-M6Er in a dog.
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U2 - 10.1111/j.1748-5827.2011.01096.x
DO - 10.1111/j.1748-5827.2011.01096.x
M3 - Article
C2 - 21797877
AN - SCOPUS:79960876281
SN - 0022-4510
VL - 52
SP - 445
EP - 447
JO - Journal of Small Animal Practice
JF - Journal of Small Animal Practice
IS - 8
ER -
