Spinocerebellar ataxia: Localization of an autosomal dominant locus between two markers on human chromosome 6

Inhertied spinocerebellar ataxias (SCA) are progressively degenerative neurological diseases. The primary site of degeneration is the cerebellar cortex - in particular, the Purkinje cells. In the present report, the SCA locus, inherited as an autosomal dominant trait in a large kindred, is localized to a region ~ 15 centimorgans telomeric of HLA-A on the short arm of chromosome 6.