Abstract
Inhertied spinocerebellar ataxias (SCA) are progressively degenerative neurological diseases. The primary site of degeneration is the cerebellar cortex - in particular, the Purkinje cells. In the present report, the SCA locus, inherited as an autosomal dominant trait in a large kindred, is localized to a region ~ 15 centimorgans telomeric of HLA-A on the short arm of chromosome 6.
Original language | English (US) |
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Pages (from-to) | 524-531 |
Number of pages | 8 |
Journal | American Journal of Human Genetics |
Volume | 41 |
Issue number | 4 |
State | Published - 1987 |