Abstract
Spinal acute opioid tolerance remains mechanistically undercharacterized. Expanded clinical use of direct spinal administration of opioids and other analgesics indicates that studies to further understand spinal mechanisms of analgesic tolerance are warranted. Rodent models of spinal administration facilitate this objective. Specifically, acute spinal opioid tolerance in mice presents a plasticity-dependent, rapid, and efficient opportunity for evaluation of novel clinical agents. Similarities between the pharmacology of acute and chronic spinal opioid tolerance, neuropathic pain, and learning and memory suggest that this model may serve as a high through-put predictor of bioactivity of novel plasticity-modifying compounds. Copyright (C) 2000 National Science Council.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 200-212 |
| Number of pages | 13 |
| Journal | Journal of biomedical science |
| Volume | 7 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2000 |
Bibliographical note
Funding Information:This research was supported by NIH/R01-DA-04274 and ADAMHA training grant T32A07234 awarded by NIDA. The design and conduct of studies were assisted by expertise provided by Ms. Tina Bushy, Mr. Kelley F. Kitto, Mr. Ivan P. Posthumus, Ms. H. Oanh Nguyen, Dr. Robert P. Yezierski, Dr. Tinna M. Laughlin, Dr. Laura S. Stone, and Dr. John Bethea.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
Keywords
- Cytokine
- Interleukins, IL-10, IL-1ra
- NMDA
- Plasticity
- Tolerance