Spinal cord injury-induced osteoporosis: Pathogenesis and emerging therapies

Ricardo A. Battaglino, Antonio A. Lazzari, Eric Garshick, Leslie R. Morse

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

Spinal cord injury causes rapid, severe osteoporosis with increased fracture risk. Mechanical unloading after paralysis results in increased osteocyte expression of sclerostin, suppressed bone formation, and indirect stimulation of bone resorption. At this time, there are no clinical guidelines to prevent bone loss after SCI, and fractures are common. More research is required to define the pathophysiology and epidemiology of SCI-induced osteoporosis. This review summarizes emerging therapeutics including antisclerostin antibodies, mechanical loading of the lower extremity with electrical stimulation, and mechanical stimulation via vibration therapy.

Original languageEnglish (US)
Pages (from-to)278-285
Number of pages8
JournalCurrent Osteoporosis Reports
Volume10
Issue number4
DOIs
StatePublished - Dec 1 2012
Externally publishedYes

Keywords

  • Bone mineral density
  • Mechanical unloading
  • Osteoporosis
  • Sclerostin
  • Spinal cord injury

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