Spin-state rationale for the peroxo-stabilizing role of the thiolate ligand in superoxide reductase

Michael R. Bukowski, Heather L. Halfen, Tieme A. Van Den Berg, Jason A. Halfen, Lawrence Que

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Anti-push: The axial thiolate ligand stabilizes high-spin Fe III-OOR species (see picture) such as those found in superoxide reductase. This situation is in contrast to the "push effect" observed in structurally similar low-spin FeIII-OOR systems, including cytochrome P450, which promote O-O bond cleavage. These results show how very similar enzyme-active sites can carry out two very different functions.

Original languageEnglish (US)
Pages (from-to)584-587
Number of pages4
JournalAngewandte Chemie - International Edition
Volume44
Issue number4
DOIs
StatePublished - Jan 14 2005

Keywords

  • Bioinorganic chemistry
  • Coordination compounds
  • Iron
  • Peroxides
  • S ligands

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