SPECT perfusion patterns distinguish psychogenic from essential tremor

K. Czarnecki, D. T. Jones, M. S. Burnett, B. Mullan, J. Y. Matsumoto

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Background: Psychogenic movement disorders pose formidable challenges to diagnosis and treatment reflecting our limited understanding of the basic brain mechanisms that cause them. Recently, functional brain imaging has been utilized to study psychogenic movement disorders. Objectives: To identify characteristic patterns of cerebral perfusion distinguishing psychogenic tremor (PT) from essential tremor (ET). Methods: We studied five patients each with PT, ET and normal controls. SPECT imaging was performed at rest and during a tremor-inducing motor task. Results: In ET, rest imaging revealed increased rCBF (relative cerebral blood flow) in cerebellar hemispheres and left inferior frontal gyrus. During the motor task, ET patients demonstrated increased rCBF in the supplementary motor area (SMA) and contralateral motor cortex and reduced rCBF in the cerebellum and visual cortex. In contrast, PT images at rest revealed increased rCBF in left inferior frontal gyrus and left insula. Motor task imaging revealed increased rCBF in the cerebellum and reduced rCBF in anterior regions of the default mode network. Conclusions: Our study revealed distinct patterns of cerebral perfusion during rest and motor task that distinguish PT from ET. Deactivation of the default mode network may serve as a marker for psychogenic movement disorders.

Original languageEnglish (US)
Pages (from-to)328-332
Number of pages5
JournalParkinsonism and Related Disorders
Volume17
Issue number5
DOIs
StatePublished - Jun 2011
Externally publishedYes

Bibliographical note

Funding Information:
The study was funded by the Mayo Foundation. The authors wish to express appreciation to Terry Brinkman, Department of Radiology, Mayo Clinic-Rochester, for her assistance with study organization and Timothy Hardyman, Department of Radiology, Mayo Clinic - Rochester, for his technical assistance.

Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.

Keywords

  • Conversion disorder
  • Prefrontal cortex
  • Single photon emission computed tomography
  • Tremor

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