Specimen histology after one or two preoperative CF-252 implants for bulky stage IB cervical cancer

Yosh Maruyama, John R. van Nagell, Jose M. Feola, J. Lawrence Beach, Justine Yoneda, Elvis Donaldson, Holly Gallion, Ken Rowley, Deborah Powell

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Using hysterectomy specimens obtained 1 month after Cf-252 neutron brachytherapy plus fractionated radiotherapy, we determined the fraction of positive and negative specimens with neutron dose for bulky Stage IB cervical cancers. The specimens obtained and studied after an initial Cf-252 insertion when the sources were newer and less decayed were more frequently negative for histological evidence of cancer than after the sources had decayed and 2 insertions were needed. After two insertions to deliver a therapeutic dose preoperatively the specimens were more frequently positive. When a larger initial dose was delivered to the tumor a larger proportion of negative specimens was noted. The size of neutron dose fraction was important to local tumor clearance and to rendering the specimens negative as well as schedule in use.

Original languageEnglish (US)
Pages (from-to)1473-1478
Number of pages6
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume13
Issue number10
DOIs
StatePublished - Oct 1987

Keywords

  • Cervix
  • Cf-252
  • Histology
  • Neutron brachytherapy
  • Number implants
  • Pre-operative

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