Specificity and Durability of Changes in Auditory Processing Efficiency After Targeted Cognitive Training in Individuals With Recent-Onset Psychosis

Bruno Biagianti, Melissa Fisher, Rachel Loewy, Benjamin Brandrett, Catalina Ordorica, Kristin LaCross, Brandon Schermitzler, Michelle McDonald, Ian Ramsay, Sophia Vinogradov

Research output: Contribution to journalArticlepeer-review

Abstract

Background: We previously demonstrated that the high heterogeneity of response to computerized Auditory Training (AT) in psychosis can be ascribed to individual differences in sensory processing efficiency and neural plasticity. In particular, we showed that Auditory Processing Speed (APS) serves as a behavioral measure of target engagement, with faster speed predicting greater transfer effects to untrained cognitive domains. Here, we investigate whether the ability of APS to function as a proxy for target engagement is unique to AT, or if it applies to other training interventions, such as Executive Functioning Training (EFT). Additionally, we examine whether changes in APS are durable after these two forms of training. Methods: One hundred and twenty-five participants with Recent Onset Psychosis (ROP) were randomized to AT (n = 66) and EFT (n = 59), respectively. APS was captured at baseline, after treatment, and at 6-month follow-up. Mixed models repeated measures analysis with restricted maximum likelihood was used to examine whether training condition differentiated APS trajectories. Within-group correlational analyses were used to study the relationship between APS and performance improvements in each of the training exercises. Results: The two groups were matched for age, gender, education, and baseline APS. Participants showed high inter-individual variability in APS at each time point. The mixed model showed a significant effect of time (F = 5.99, p =.003) but not a significant group-by-time effect (F =.73, p =.48). This was driven by significant APS improvements AT patients after treatment (d =.75) that were maintained after 6 months (d =.63). Conversely, in EFT patients, APS improvements did not reach statistical significance after treatment (p =.33) or after 6 months (p =.24). In AT patients, baseline APS (but not APS change) highly predicted peak performance for each training exercise (all r’s >.42). Conclusions: Participant-specific speed in processing basic auditory stimuli greatly varies in ROP, and strongly influences the magnitude of response to auditory but not executive functioning training. Importantly, enhanced auditory processing efficiency persists 6 months after AT, suggesting the durability of neuroplasticity processes induced by this form of training. Future studies should aim to identify markers of target engagement and durability for cognitive training interventions that target sensory modalities beyond the auditory domain.

Original languageEnglish (US)
Article number857
JournalFrontiers in Psychiatry
Volume11
DOIs
StatePublished - Aug 28 2020

Bibliographical note

Funding Information:
Research reported in this publication was supported by the National Center for Advancing Translational Sciences of the National Institutes of Health Award Number UL1-TR002494. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Publisher Copyright:
© Copyright © 2020 Biagianti, Fisher, Loewy, Brandrett, Ordorica, LaCross, Schermitzler, McDonald, Ramsay and Vinogradov.

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

  • cognitive training
  • early psychosis
  • neuroplasticity
  • personalized medicine
  • target engagement

PubMed: MeSH publication types

  • Journal Article

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