Specific Targeting of Melanotic Cells with Peptide Ligated Photosensitizers for Photodynamic Therapy

Paul Lorenz Bigliardi; Bhimsen Rout; Aakanksha Pant; Viknish Krishnan-Kutty; Alex N. Eberle; Ramasamy Srinivas; Brendan Adrian Burkett; Mei Bigliardi-Qi

doi:10.1038/s41598-017-15142-w

Specific Targeting of Melanotic Cells with Peptide Ligated Photosensitizers for Photodynamic Therapy

Paul Lorenz Bigliardi, Bhimsen Rout, Aakanksha Pant, Viknish Krishnan-Kutty, Alex N. Eberle, Ramasamy Srinivas, Brendan Adrian Burkett, Mei Bigliardi-Qi

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A strategy combining covalent conjugation of photosensitizers to a peptide ligand directed to the melanocortin 1 (MC1) receptor with the application of sequential LED light dosage at near-IR wavelengths was developed to achieve specific cytotoxicity to melanocytes and melanoma (MEL) with minimal collateral damage to surrounding cells such as keratinocytes (KER). The specific killing of melanotic cells by targeted photodynamic therapy (PDT) described in this study holds promise as a potentially effective adjuvant therapeutic method to control benign skin hyperpigmentation or superficial melanotic malignancy such as Lentigo Maligna Melanoma (LMM).

Original language	English (US)
Article number	15750
Journal	Scientific reports
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s41598-017-15142-w
State	Published - Dec 1 2017
Externally published	Yes

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Publisher Copyright:
© 2017 The Author(s).

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10.1038/s41598-017-15142-w

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691209

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abstract = "A strategy combining covalent conjugation of photosensitizers to a peptide ligand directed to the melanocortin 1 (MC1) receptor with the application of sequential LED light dosage at near-IR wavelengths was developed to achieve specific cytotoxicity to melanocytes and melanoma (MEL) with minimal collateral damage to surrounding cells such as keratinocytes (KER). The specific killing of melanotic cells by targeted photodynamic therapy (PDT) described in this study holds promise as a potentially effective adjuvant therapeutic method to control benign skin hyperpigmentation or superficial melanotic malignancy such as Lentigo Maligna Melanoma (LMM).",

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AU - Bigliardi, Paul Lorenz

AU - Rout, Bhimsen

AU - Pant, Aakanksha

AU - Krishnan-Kutty, Viknish

AU - Eberle, Alex N.

AU - Srinivas, Ramasamy

AU - Burkett, Brendan Adrian

AU - Bigliardi-Qi, Mei

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Specific Targeting of Melanotic Cells with Peptide Ligated Photosensitizers for Photodynamic Therapy

Abstract

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