Specific reversal of cytolytic T lymphocyte-target cell interaction

S. P. Balk, M. F. Mescher

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

A functional assay is described that measures the reversal of specific cytolytic T cell (CTL)-target cell binding. Binding of 51Cr-labeled P815 cells was stable in suspension but could be readily reversed by the addition of unlabeled P815 cells. The reversal of CTL-tumor cell and CTL-spleen cell binding was H-2 specific; only cells of the same H-2 type as the bound target cell could induce reversal. In all cases, tumor cells were substantially more efficient than spleen cells in inducing specific reversal.

Original languageEnglish (US)
Pages (from-to)43-52
Number of pages10
JournalJournal of Supramolecular and Cellular Biochemistry
Volume16
Issue number1
DOIs
StatePublished - Jan 1 1981

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