Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains

Keyphrases

• Specific Inhibition 100%
• Kinetic Analysis 100%
• ATP Synthase 100%
• Valosin-containing Protein 100%
• ATPase Domain 100%
• P97 Inhibitor 100%
• Kcat 66%
• Walker A 66%
• Walker B 66%
• Therapeutic Target 33%
• Small Molecule Inhibitors 33%
• AAA+ ATPase 33%
• Differential Effects 33%
• Therapeutic Agents 33%
• Neurodegenerative Diseases 33%
• Differential Response 33%
• Cancer Disease 33%
• Linker 33%
• Catalytic Efficiency 33%
• N-terminal Domain 33%
• ATP Hydrolysis 33%
• Cause of Disease 33%
• Hexamer 33%
• Disease-causing mutations 33%
• Nucleotide Binding 33%
• N-domain 33%
• ATPases Associated with Diverse Cellular Activities 33%
• IBMPFD 33%
• DBeQ 33%
• Developing Context 33%
• NMS-873 33%
• 2D Domain 33%
• Inhibitor Potency 33%
• Stacked Rings 33%

Biochemistry, Genetics and Molecular Biology

• P97 100%
• Kinetics 100%
• ATPase 100%
• Valosin-Containing Protein 100%
• Adenosine Triphosphate 33%
• Enzymatic Hydrolysis 22%
• Turnover Number 22%
• Small Molecule 11%
• N-Terminus 11%
• Binding Domain 11%
• AAA Protein 11%
• Catalytic Efficiency 11%
• AAA Domain 11%