Spatiotemporal expansion of primary progenitor zones in the developing human cerebellum

Parthiv Haldipur, Kimberly A. Aldinger, Silvia Bernardo, Mei Deng, Andrew E. Timms, Lynne M. Overman, Conrad Winter, Steven N. Lisgo, Ferechte Razavi, Evelina Silvestri, Lucia Manganaro, Homa Adle-Biasette, Fabien Guilmiot, Rosa Russo, Debora Kidron, Patrick R. Hof, Dianne Gerrelli, Susan J. Lindsay, William B. Dobyns, Ian A. GlassPaula Alexandre, Kathleen J. Millen

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

We present histological and molecular analyses of the developing human cerebellum from 30 days after conception to 9 months after birth. Differences in developmental patterns between humans and mice include spatiotemporal expansion of both ventricular and rhombic lip primary progenitor zones to include subventricular zones containing basal progenitors. The human rhombic lip persists longer through cerebellar development than in the mouse and undergoes morphological changes to form a progenitor pool in the posterior lobule, which is not seen in other organisms, not even in the nonhuman primate the macaque. Disruptions in human rhombic lip development are associated with posterior cerebellar vermis hypoplasia and Dandy-Walker malformation. The presence of these species-specific neural progenitor populations refines our insight into human cerebellar developmental disorders.

Original languageEnglish (US)
Pages (from-to)454-460
Number of pages7
JournalScience
Volume366
Issue number6464
DOIs
StatePublished - Oct 25 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019 American Association for the Advancement of Science. All rights reserved.

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