Spatiotemporal and spatial threshold models for relating UV exposures and skin cancer in the central United States

Laura A. Hatfield, Richard W. Hoffbeck, Bruce H Alexander, Brad Carlin

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The exact mechanisms relating exposure to ultraviolet (UV) radiation and elevated risk of skin cancer remain the subject of debate. For example, there is disagreement on whether the main risk factor is duration of the exposure, its intensity, or some combination of both. There is also uncertainty regarding the form of the dose-response curve, with many authors believing only exposures exceeding a given (but unknown) threshold are important. This paper explores methods to estimate such thresholds using hierarchical spatial logistic models based on a sample of a cohort of x-ray technologists for whom self-reports of time spent in the sun and numbers of blistering sunburns in childhood are available. A preliminary goal is to explore the temporal pattern of UV exposure and its gradient. Changes would imply that identical exposure self-reports from different calendar years may correspond to differing cancer risks.

Original languageEnglish (US)
Pages (from-to)3001-3015
Number of pages15
JournalComputational Statistics and Data Analysis
Volume53
Issue number8
DOIs
StatePublished - Jun 15 2009

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