Spatio-temporal EEG source localization using a three-dimensional subspace FINE approach in a realistic geometry inhomogeneous head model

Lei Ding, Bin He

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

The subspace source localization approach, i.e., first principle vectors (FINE), is able to enhance the spatial resolvability and localization accuracy for closely-spaced neural sources from EEG and MEG measurements. Computer simulations were conducted to evaluate the performance of the FINE algorithm in an inhomogeneous realistic geometry head model under a variety of conditions. The source localization abilities of FINE were examined at different cortical regions and at different depths. The present computer simulation results indicate that FINE has enhanced source localization capability, as compared with MUSIC and RAP-MUSIC, when sources are closely spaced, highly noise-contaminated, or inter-correlated. The source localization accuracy of FINE is better, for closely-spaced sources, than MUSIC at various noise levels, i.e., signal-to-noise ratio (SNR) from 6 dB to 16 dB, and RAP-MUSIC at relatively low noise levels, i.e., 6 dB to 12 dB. The FINE approach has been further applied to localize brain sources of motor potentials, obtained during the finger tapping tasks in a human subject. The experimental results suggest that the detailed neural activity distribution could be revealed by FINE. The present study suggests that FINE provides enhanced performance in localizing multiple closely spaced, and inter-correlated sources under low SNR, and may become an important alternative to brain source localization from EEG or MEG.

Original languageEnglish (US)
Article number1673615
Pages (from-to)1732-1739
Number of pages8
JournalIEEE Transactions on Biomedical Engineering
Volume53
Issue number9
DOIs
StatePublished - Sep 2006

Bibliographical note

Funding Information:
Manuscript received July 22, 2005; revised January 29, 2006. This work was supported in part by the National Institutes of Health (NIH) under Grant NIH R01EB00178, in part by the National Science Foundation (NSF) under Grant NSF-BES-0411898 and Grant NSF-BES-0411480, and in part by the Biomedical Engineering Institute at the University of Minnesota. Asterisk indicates corresponding author.

Keywords

  • Brain mapping
  • EEG
  • Electrophysiological neuroimaging
  • FINE
  • Inverse problem
  • MEG
  • MUSIC
  • Source localization
  • Subspace

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