Spatially‐localized NMR spectroscopy employing an inhomogeneous surface‐spoiling magnetic field gradient 2. Surface coil experiments with multicompartment phantom and rat in vivo

Wei Chen, Joseph J.H. Ackerman

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

The use of inhomogeneous surface‐spoiling magnetic field gradients for elimination of signal from surface lying regions of a sample was theoretically examined in the companion article (W. Chen and J. J. H. Ackerman, NMR Biomed. 3, 147–157 (1990)). Using the spoiling gradient coil design described therein, this article presents experimental verification of the feasibility of such an approach to enhanced spatial localization. Single coil mode 31P NMR surface coil interrogation of both a two compartment phantom and rat in vivo are shown to provide excellent suppression of surface lying regions with minimal degradation of signal from the deep lying region of interest. Both pulse‐and‐collect and spin echo sequences were highly efficient in concert with spoiling gradient periods of 0.5–2 ms and driving currents of 0.5–2 A. The use of a current‐generated surface spoiling gradient offers a robust means to remove surface tissue signal contributions and can be implemented with a wide range of localizing pulse sequences and imaging protocols.

Original languageEnglish (US)
Pages (from-to)158-165
Number of pages8
JournalNMR in biomedicine
Volume3
Issue number4
DOIs
StatePublished - Aug 1990

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Magnetic Fields
Nuclear magnetic resonance spectroscopy
Rats
Magnetic Resonance Spectroscopy
Magnetic fields
Experiments
Nuclear magnetic resonance
Tissue
Imaging techniques
Network protocols
Degradation

Cite this

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title = "Spatially‐localized NMR spectroscopy employing an inhomogeneous surface‐spoiling magnetic field gradient 2. Surface coil experiments with multicompartment phantom and rat in vivo",
abstract = "The use of inhomogeneous surface‐spoiling magnetic field gradients for elimination of signal from surface lying regions of a sample was theoretically examined in the companion article (W. Chen and J. J. H. Ackerman, NMR Biomed. 3, 147–157 (1990)). Using the spoiling gradient coil design described therein, this article presents experimental verification of the feasibility of such an approach to enhanced spatial localization. Single coil mode 31P NMR surface coil interrogation of both a two compartment phantom and rat in vivo are shown to provide excellent suppression of surface lying regions with minimal degradation of signal from the deep lying region of interest. Both pulse‐and‐collect and spin echo sequences were highly efficient in concert with spoiling gradient periods of 0.5–2 ms and driving currents of 0.5–2 A. The use of a current‐generated surface spoiling gradient offers a robust means to remove surface tissue signal contributions and can be implemented with a wide range of localizing pulse sequences and imaging protocols.",
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T1 - Spatially‐localized NMR spectroscopy employing an inhomogeneous surface‐spoiling magnetic field gradient 2. Surface coil experiments with multicompartment phantom and rat in vivo

AU - Chen, Wei

AU - Ackerman, Joseph J.H.

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Y1 - 1990/8

N2 - The use of inhomogeneous surface‐spoiling magnetic field gradients for elimination of signal from surface lying regions of a sample was theoretically examined in the companion article (W. Chen and J. J. H. Ackerman, NMR Biomed. 3, 147–157 (1990)). Using the spoiling gradient coil design described therein, this article presents experimental verification of the feasibility of such an approach to enhanced spatial localization. Single coil mode 31P NMR surface coil interrogation of both a two compartment phantom and rat in vivo are shown to provide excellent suppression of surface lying regions with minimal degradation of signal from the deep lying region of interest. Both pulse‐and‐collect and spin echo sequences were highly efficient in concert with spoiling gradient periods of 0.5–2 ms and driving currents of 0.5–2 A. The use of a current‐generated surface spoiling gradient offers a robust means to remove surface tissue signal contributions and can be implemented with a wide range of localizing pulse sequences and imaging protocols.

AB - The use of inhomogeneous surface‐spoiling magnetic field gradients for elimination of signal from surface lying regions of a sample was theoretically examined in the companion article (W. Chen and J. J. H. Ackerman, NMR Biomed. 3, 147–157 (1990)). Using the spoiling gradient coil design described therein, this article presents experimental verification of the feasibility of such an approach to enhanced spatial localization. Single coil mode 31P NMR surface coil interrogation of both a two compartment phantom and rat in vivo are shown to provide excellent suppression of surface lying regions with minimal degradation of signal from the deep lying region of interest. Both pulse‐and‐collect and spin echo sequences were highly efficient in concert with spoiling gradient periods of 0.5–2 ms and driving currents of 0.5–2 A. The use of a current‐generated surface spoiling gradient offers a robust means to remove surface tissue signal contributions and can be implemented with a wide range of localizing pulse sequences and imaging protocols.

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