TY - GEN
T1 - Spatial resolution and heterogeneity of local field potentials in the globus pallidus
AU - Connolly, Allison T.
AU - Agnesi, Filippo
AU - Johnson, Matthew D.
PY - 2013
Y1 - 2013
N2 - Local field potentials (LFPs) are thought to be promising feedback signals for implementation in closed-loop deep brain stimulation (DBS) systems. However, little is known about how spectral properties of bipolar LFPs recorded along a DBS lead depend on electrode size and spacing. In this study, we recorded LFPs from two different DBS lead designs spanning the external globus pallidus (GPe) and internal globus pallidus (GPi) in two non-human primates. Bipolar electrode recording montages were progressively grouped to investigate spatial heterogeneity of oscillatory activity in the beta (10-30 Hz) and high gamma (>70 Hz) frequencies. For both DBS leads, the data showed that the highest ratio of beta to gamma activity within the GPi. The stronger ratio of beta to gamma was found for a bipolar electrode pitch of 750 μm compared to 1000 μm, while a larger inter-electrode spacing of 1.5-3 mm with one contact in the GPe and the other in the GPi produced the strongest activity. Finally, oscillatory activity recorded within the same region of globus pallidus with a bipolar electrode montage oriented longitudinally versus radially did not differ significantly. Together, these data provide important guidelines for the design of recording electrodes for use with closed-loop DBS leads in the globus pallidus.
AB - Local field potentials (LFPs) are thought to be promising feedback signals for implementation in closed-loop deep brain stimulation (DBS) systems. However, little is known about how spectral properties of bipolar LFPs recorded along a DBS lead depend on electrode size and spacing. In this study, we recorded LFPs from two different DBS lead designs spanning the external globus pallidus (GPe) and internal globus pallidus (GPi) in two non-human primates. Bipolar electrode recording montages were progressively grouped to investigate spatial heterogeneity of oscillatory activity in the beta (10-30 Hz) and high gamma (>70 Hz) frequencies. For both DBS leads, the data showed that the highest ratio of beta to gamma activity within the GPi. The stronger ratio of beta to gamma was found for a bipolar electrode pitch of 750 μm compared to 1000 μm, while a larger inter-electrode spacing of 1.5-3 mm with one contact in the GPe and the other in the GPi produced the strongest activity. Finally, oscillatory activity recorded within the same region of globus pallidus with a bipolar electrode montage oriented longitudinally versus radially did not differ significantly. Together, these data provide important guidelines for the design of recording electrodes for use with closed-loop DBS leads in the globus pallidus.
UR - https://www.scopus.com/pages/publications/84897722624
UR - https://www.scopus.com/pages/publications/84897722624#tab=citedBy
U2 - 10.1109/NER.2013.6695888
DO - 10.1109/NER.2013.6695888
M3 - Conference contribution
AN - SCOPUS:84897722624
SN - 9781467319690
T3 - International IEEE/EMBS Conference on Neural Engineering, NER
SP - 129
EP - 132
BT - 2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013
T2 - 2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013
Y2 - 6 November 2013 through 8 November 2013
ER -