Spatial relationship between neuronal activity and BOLD functional MRI

Dae Shik Kim; Itamar Ronen; Cheryl A Olman; Seong Gi Kim; Kamil Ugurbil; Louis J. Toth

doi:10.1016/j.neuroimage.2003.10.018

Spatial relationship between neuronal activity and BOLD functional MRI

Dae Shik Kim, Itamar Ronen, Cheryl A Olman, Seong Gi Kim, Kamil Ugurbil, Louis J. Toth

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Abstract

Despite the ubiquitous use of functional magnetic resonance imaging (fMRI), the extent to which the magnitude and spatial scale of the fMRI signal correlates with neuronal activity is poorly understood. In this study, we directly compared single and multiunit neuronal activity with blood oxygenation level-dependent (BOLD) fMRI responses across a large area of the cat area 18. Our data suggest that at the scale of several millimeters, the BOLD contrast correlates linearly with the underlying neuronal activity. At the level of individual electrode recording sites, however, the correlation between the two signals varied substantially. We conclude from our study that T ₂*-based positive BOLD signals are a robust predictor for neuronal activity only at supra-millimeter spatial scales.

Original language	English (US)
Pages (from-to)	876-885
Number of pages	10
Journal	NeuroImage
Volume	21
Issue number	3
DOIs	https://doi.org/10.1016/j.neuroimage.2003.10.018
State	Published - Mar 2004

Bibliographical note

Funding Information:
We thank Drs. T. Duong and N. Harel for their assistance during some of the initial experiments. N. Port from NIH provided the initial recording chambers for testing. This work was supported by the NIH (MH57180, MH67530, NS38295, RR08079), the W.M. Keck Foundation, and the Whitaker Foundation, NARSAD.

Keywords

BOLD
Neuronal activity
fMRI

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10.1016/j.neuroimage.2003.10.018

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title = "Spatial relationship between neuronal activity and BOLD functional MRI",

abstract = "Despite the ubiquitous use of functional magnetic resonance imaging (fMRI), the extent to which the magnitude and spatial scale of the fMRI signal correlates with neuronal activity is poorly understood. In this study, we directly compared single and multiunit neuronal activity with blood oxygenation level-dependent (BOLD) fMRI responses across a large area of the cat area 18. Our data suggest that at the scale of several millimeters, the BOLD contrast correlates linearly with the underlying neuronal activity. At the level of individual electrode recording sites, however, the correlation between the two signals varied substantially. We conclude from our study that T 2*-based positive BOLD signals are a robust predictor for neuronal activity only at supra-millimeter spatial scales.",

keywords = "BOLD, Neuronal activity, fMRI",

author = "Kim, {Dae Shik} and Itamar Ronen and Olman, {Cheryl A} and Kim, {Seong Gi} and Kamil Ugurbil and Toth, {Louis J.}",

note = "Funding Information: We thank Drs. T. Duong and N. Harel for their assistance during some of the initial experiments. N. Port from NIH provided the initial recording chambers for testing. This work was supported by the NIH (MH57180, MH67530, NS38295, RR08079), the W.M. Keck Foundation, and the Whitaker Foundation, NARSAD.",

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doi = "10.1016/j.neuroimage.2003.10.018",

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T1 - Spatial relationship between neuronal activity and BOLD functional MRI

AU - Kim, Dae Shik

AU - Ronen, Itamar

AU - Olman, Cheryl A

AU - Kim, Seong Gi

AU - Ugurbil, Kamil

AU - Toth, Louis J.

N1 - Funding Information: We thank Drs. T. Duong and N. Harel for their assistance during some of the initial experiments. N. Port from NIH provided the initial recording chambers for testing. This work was supported by the NIH (MH57180, MH67530, NS38295, RR08079), the W.M. Keck Foundation, and the Whitaker Foundation, NARSAD.

PY - 2004/3

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N2 - Despite the ubiquitous use of functional magnetic resonance imaging (fMRI), the extent to which the magnitude and spatial scale of the fMRI signal correlates with neuronal activity is poorly understood. In this study, we directly compared single and multiunit neuronal activity with blood oxygenation level-dependent (BOLD) fMRI responses across a large area of the cat area 18. Our data suggest that at the scale of several millimeters, the BOLD contrast correlates linearly with the underlying neuronal activity. At the level of individual electrode recording sites, however, the correlation between the two signals varied substantially. We conclude from our study that T 2*-based positive BOLD signals are a robust predictor for neuronal activity only at supra-millimeter spatial scales.

AB - Despite the ubiquitous use of functional magnetic resonance imaging (fMRI), the extent to which the magnitude and spatial scale of the fMRI signal correlates with neuronal activity is poorly understood. In this study, we directly compared single and multiunit neuronal activity with blood oxygenation level-dependent (BOLD) fMRI responses across a large area of the cat area 18. Our data suggest that at the scale of several millimeters, the BOLD contrast correlates linearly with the underlying neuronal activity. At the level of individual electrode recording sites, however, the correlation between the two signals varied substantially. We conclude from our study that T 2*-based positive BOLD signals are a robust predictor for neuronal activity only at supra-millimeter spatial scales.

KW - BOLD

KW - Neuronal activity

KW - fMRI

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Spatial relationship between neuronal activity and BOLD functional MRI

Abstract

Bibliographical note

Keywords

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