Spatial and phylogenetic analysis of vesicular stomatitis virus over-wintering in the United States

Andres M. Perez, Steven J. Pauszek, Daniel Jimenez, William N. Kelley, Zachary Whedbee, Luis L. Rodriguez

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

From 2004 through 2006, 751 vesicular stomatitis (VS) outbreaks caused by vesicular stomatitis virus serotype New Jersey (VSNJV) were reported in nine states of the southwestern United States. The normal model of the spatial scan statistic and phylogenetic techniques were used to assess whether the spatial and genetic relations among VSNJV outbreaks were consistent with the hypothesis that VSNJV over-wintered in specific regions of the southwestern United States infected in 2004 and 2005, respectively. Use of the spatial scan statistic led to the identification of two clusters of outbreaks for which the Euclidean distance to the nearest outbreak reported in the previous or following year, whichever was shorter, was significantly (P < 0.01) shorter than the epidemic's (2004-2006) mean. Clusters were centered at Colorado and Wyoming and included 375 and 21 outbreaks, respectively. Results were supported by the phylogenetic analysis of 49 VSV samples collected from 2004 through 2006 in the United States and 10 VSV samples originated from Mexico. These findings, which were displayed using a publicly accessible web-based system referred to as the FMD BioPortal, were consistent with over-wintering of specific sub-lineages of VSNJV in a limited geographical region of the United States affected by a VS epidemic in 2005 and 2006.

Original languageEnglish (US)
Pages (from-to)258-264
Number of pages7
JournalPreventive Veterinary Medicine
Volume93
Issue number4
DOIs
StatePublished - Mar 1 2010

Bibliographical note

Funding Information:
This paper was funded in part by the United States National Center for Medical Intelligence, by the United States Department of Agriculture (USDA) Agricultural Research Service (ARS), and by the United States Department of Energy Oak Ridge Institute for Science and Education (ORISE).

Keywords

  • Epidemiology
  • Over-wintering
  • Phylogeny
  • Spatial clustering
  • Vesicular stomatitis virus

Fingerprint

Dive into the research topics of 'Spatial and phylogenetic analysis of vesicular stomatitis virus over-wintering in the United States'. Together they form a unique fingerprint.

Cite this