Efficient use of micronutrients can potentially increase soybean [Glycine max (L.) Merr.] grain yield and economic return. The objectives of this study were to determine the effect of broadcast application of micronutrients on soybean tissue nutrient concentration and grain yield and the relationships between soil and plant tissue tests. Three separate research trials were conducted at 35 sites from 2011 to 2014. Soybean response to Zn application was evaluated in Study 1; B, Mn, and Zn in Study 2; and B, Cl, Mn, and Zn in Study 3. Fertilizers were broadcast applied to the soil surface and incorporated prior to planting. Application of B, Cl, and Zn increased soybean trifoliate concentration of each respective nutrient but application of Mn did not. Addition of B, Cl, Mn, and Zn did not increase soybean grain yield and had a marginal impact on soybean grain quality. Application of 2.2 kg B ha–1 sometimes reduced soybean grain yield. Soil tests for B, Cl, and Zn did not predict soybean grain yield response and there were no relationships between trifoliate B, Cl, Mn, and Zn concentration to grain yield or their respective soil tests. Increased soybean grain yield did increase the removal of micronutrients, but it is unlikely that micronutrients are needed to increase soybean grain yield. Results from these studies conducted across Minnesota showed that broadcast application of B, Cl, Mn, and Zn do not increase soybean yield except for low Mn (<20 mg kg–1) where Mn application could increase soybean yield.