Sox2 cooperates with inflammation-mediated stat3 activation in the malignant transformation of foregut basal progenitor cells

Kuancan Liu, Ming Jiang, Yun Lu, Hao Chen, Jun Sun, Shaoping Wu, Wei Yao Ku, Hiroshi Nakagawa, Yoshiaki Kita, Shoji Natsugoe, Jeffrey H. Peters, Anil Rustgi, Mark W. Onaitis, Amy Kiernan, Xiaoxin Chen, Jianwen Que

Research output: Contribution to journalArticlepeer-review

112 Scopus citations

Abstract

Sox2 regulates the self-renewal of multiple types of stem cells. Recent studies suggest it also plays oncogenic roles in the formation of squamous carcinoma in several organs, including the esophagus where Sox2 is predominantly expressed in the basal progenitor cells of the stratified epithelium. Here, we use mouse genetic models to reveal a mechanism by which Sox2 cooperates with microenvironmental signals to malignantly transform epithelial progenitor cells. Conditional overexpression of Sox2 in basal cells expands the progenitor population in both the esophagus and forestomach. Significantly, carcinoma only develops in the forestomach, where pathological progression correlates with inflammation and nuclear localization of Stat3 in progenitor cells. Importantly, co-overexpression of Sox2 and activated Stat3 (Stat3C) also transforms esophageal basal cells but not the differentiated suprabasal cells. These findings indicate that basal stem/progenitor cells are the cells of origin of squamous carcinoma and that cooperation between Sox2 and microenvironment- activated Stat3 is required for Sox2-driven tumorigenesis.

Original languageEnglish (US)
Pages (from-to)304-315
Number of pages12
JournalCell Stem Cell
Volume12
Issue number3
DOIs
StatePublished - Mar 7 2013

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