Soudanones A-G: Antifungal Isochromanones from the Ascomycetous Fungus Cadophora sp. Isolated from an Iron Mine

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Abstract

One new isochromane (pseudoanguillosporin C, 2), seven isochromanones (soudanones A-G, 3-9), and six known analogues including 10 and 11 were isolated from a culture of the fungus Cadophora sp. 10-5-2 M, collected from the subterranean 10th level of the Soudan Underground Iron Mine in Minnesota. All of the compounds were tested against a panel of microbial pathogens, and 2, 3, 10, and 11 were found to have activity against Cryptococcus neoformans (MIC = 35, 40, 20, and 30 μg/mL, respectively). Compound 11 was also active against Candida albicans, with an MIC of 40 μg/mL.

Original languageEnglish (US)
Pages (from-to)1456-1460
Number of pages5
JournalJournal of Natural Products
Volume78
Issue number6
DOIs
StatePublished - Jun 26 2015

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